Abstract
Lipids and lipid metabolism have well-documented regulatory effects on inflammatory processes. Recent work has highlighted the role of the peroxisome proliferator-activated receptors (PPARs)--a subset of the nuclear-hormone-receptor superfamily that are activated by various lipid species--in regulating inflammatory responses. Here, we describe how the PPARs, through their interactions with transcription factors and other cell-signalling systems, have important regulatory roles in innate and adaptive immunity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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B-Lymphocytes / immunology
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B-Lymphocytes / metabolism
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Dendritic Cells / immunology
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Dendritic Cells / metabolism
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Humans
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Immunity, Innate
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Inflammation / drug therapy
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Inflammation / etiology*
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Ligands
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Models, Immunological
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Receptors, Cytoplasmic and Nuclear / chemistry
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Receptors, Cytoplasmic and Nuclear / immunology*
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Receptors, Cytoplasmic and Nuclear / physiology*
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Signal Transduction
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T-Lymphocytes / immunology
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T-Lymphocytes / metabolism
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Transcription Factors / chemistry
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Transcription Factors / immunology*
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Transcription Factors / physiology*
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Transcriptional Activation
Substances
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Ligands
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Receptors, Cytoplasmic and Nuclear
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Transcription Factors