The role of Toll-like receptors in immunity against mycobacterial infection

Microbes Infect. 2002 Jul;4(9):937-44. doi: 10.1016/s1286-4579(02)01611-8.

Abstract

Recent work implicates Toll-like receptor (TLR) proteins as regulators of innate immune cell activation induced by Mycobacterium tuberculosis, which continues to ravage nearly one-third of the world's population. Novel insights into how TLR proteins may dictate the nature and extent of cellular immune responses against this pathogen will be discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation
  • Antigen-Presenting Cells / immunology
  • Apoptosis
  • Drosophila Proteins*
  • Humans
  • Immunity, Innate*
  • Membrane Glycoproteins / agonists
  • Membrane Glycoproteins / metabolism*
  • Mycobacterium tuberculosis / immunology*
  • Mycobacterium tuberculosis / pathogenicity
  • Receptors, Cell Surface / agonists
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction
  • Toll-Like Receptors
  • Tuberculosis / immunology*

Substances

  • Drosophila Proteins
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors