Abstract
T regulatory cells-in addition to clonal deletion and anergy-are essential for the downregulation of T cell responses to both foreign and self antigens, and for the prevention of autoimmunity. Recent progress has been made in characterising the different subsets of T regulatory cells, the factors that drive their differentiation, and their mode of action. The resolution of these mechanisms will make it possible to use T regulatory cells therapeutically in human autoimmune diseases.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autoimmunity / immunology*
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CD4-Positive T-Lymphocytes / cytology
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CD4-Positive T-Lymphocytes / immunology*
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Cell Differentiation
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Clonal Anergy / immunology
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Cytokines / immunology
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Humans
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Leukocyte Common Antigens / immunology
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Receptors, Interleukin-2 / immunology
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T-Lymphocyte Subsets / immunology*
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T-Lymphocytes, Helper-Inducer / immunology
Substances
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Cytokines
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Receptors, Interleukin-2
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Leukocyte Common Antigens