Abstract
We studied tone in the human ductus arteriosus and show that the constriction to oxygen is due to inhibition of voltage-gated potassium channels and, in the acute phase, is independent of endothelin-1.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Aminopyridine / pharmacology
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Charybdotoxin / pharmacology
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Cyclooxygenase Inhibitors / pharmacology
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Ductus Arteriosus / ultrastructure*
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Ductus Arteriosus, Patent / metabolism*
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Endothelin-1 / drug effects
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Endothelin-1 / physiology*
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Glyburide / pharmacology
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Humans
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Hypoxia / metabolism*
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Ion Channel Gating / drug effects
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Ion Channel Gating / physiology*
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Membrane Potentials
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Muscle, Smooth, Vascular / drug effects
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Nitric Oxide Synthase / antagonists & inhibitors
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Oxygen Consumption / drug effects
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Oxygen Consumption / physiology*
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Potassium Channels / drug effects
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Potassium Channels / physiology*
Substances
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Cyclooxygenase Inhibitors
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Endothelin-1
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Potassium Channels
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Charybdotoxin
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4-Aminopyridine
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Nitric Oxide Synthase
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Glyburide