Abstract
While CD28 is critical for expansion of naive T cells, recent evidence suggests that the activation of effector T cells is largely independent of CD28/B7. We suggest that ICOS, the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL-5, and IFNgamma from recently activated T cells and contributes to T cell-dependent B help in vivo. Inhibition of ICOS attenuates lung mucosal inflammation induced by Th2 but not Th1 effector populations. Our data indicate a critical function for the third member of the CD28 family in T cell-dependent immune responses.
MeSH terms
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Abatacept
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Animals
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Antigens, CD
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Antigens, Differentiation / immunology
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Antigens, Differentiation, T-Lymphocyte / genetics
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Antigens, Differentiation, T-Lymphocyte / immunology*
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CD28 Antigens / immunology*
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CTLA-4 Antigen
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Cloning, Molecular
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Cytokines / biosynthesis
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Gene Expression
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Humans
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Immunoconjugates*
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Immunoglobulin G / biosynthesis
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Immunoglobulin M / biosynthesis
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Inducible T-Cell Co-Stimulator Protein
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Jurkat Cells
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Transgenic
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Signal Transduction
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Th1 Cells / immunology*
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Th2 Cells / immunology*
Substances
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Antigens, CD
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Antigens, Differentiation
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Antigens, Differentiation, T-Lymphocyte
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CD28 Antigens
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CTLA-4 Antigen
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CTLA4 protein, human
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Ctla4 protein, mouse
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Cytokines
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ICOS protein, human
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Icos protein, mouse
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Immunoconjugates
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Immunoglobulin G
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Immunoglobulin M
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Inducible T-Cell Co-Stimulator Protein
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Abatacept