The model of chronic intrauterine hypoxia was made according to the method, devised in physiology and experimental medicine laboratory of Institute of Pediatrics, Obstetrics and Gynecology Ukrainian AM Sci. This method consist in dose narrowing of the basal venous columns from cornua of uterus in rabbits on 14-15 days of pregnancy. The obtained experimental results confirm previous clinical date about disturbances in antistress mechanisms of protection under chronic fetus hypoxia. Evidently, this disturbances are the important pathogenetic links in behinding of newborn rabbits in physical development and, especially, in its lethality.