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Home / The International Journal of Tuberculosis and Lung Disease, Volume 16, Number 2

Fluoroquinolone and pyrazinamide resistance in multidrug-resistant tuberculosis [Short communication]

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In a study performed in Cambodia, a higher number of tuberculosis (TB) strains with mutations in the pncA gene associated with pyrazinamide resistance (PZA-R) was found in fluoroquinolone-resistant (FQ-R) multidrug-resistant (MDR) strains (93%), compared with 47% in MDR and 3% in non-MDR strains. This emphasises the need for easy and rapid tests for identification of PZA-R for efficient treatment of MDR-TB.

Keywords: MDR-TB; fluoroquinolone; pyrazinamide

Document Type: Research Article

Affiliations: 1: Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France 2: Mycobacteriology Laboratory, Institut Pasteur in Cambodia, Phnom Penh, Cambodia

Publication date: 01 February 2012

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