Case ReportObstructive Sleep Apnea Due to Endogenous Testosterone Production in a Woman
Section snippets
DISCUSSION
Obstructive sleep apnea (OSA) is a common medical condition characterized by repetitive episodes of upper airway obstruction that manifest clinically with snoring, apneas, restless sleep, daytime somnolence, and hypertension.2, 3 It is more common in men than in women4 and is more common in postmenopausal women than in premenopausat women.5 These findings have led to the hypothesis that reproductive hormones have a role in the cause of OSA.
In one study, a treatment trial of medroxyprogesterone
CONCLUSION
Our patient's symptoms resolved after her tumor was removed. This unique case further supports the theory of male hormonal influence in the OSA syndrome.
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Sex-specific differences in patients with obstructive sleep apnea-hypopnea syndrome
2023, Encyclopedia of Sleep and Circadian Rhythms: Volume 1-6, Second EditionObesity may be the common pathway for sleep-disordered breathing in women with polycystic ovary syndrome
2016, Sleep MedicineCitation Excerpt :Being a cross-sectional study, it may be difficult to establish a cause-and-effect relationship between testosterone and increased occurrence of SDB in PCOS patients in our study. However, the role of testosterone in the causation of SDB has been suggested by many researchers [30,43–45]. Fogel et al. [30] also found an increased prevalence of SDB in obese patients with PCOS in comparison with age- and weight-matched control subjects (44.4% vs 5.5%) and a positive correlation between the severity of SDB and androgen levels.
Medication effects on sleep and breathing
2014, Clinics in Chest MedicineCitation Excerpt :In a published case report, a woman with a testosterone-producing tumor had concurrent OSA. When the tumor was resected, her testosterone level normalized and her OSA resolved.114 Obese women with polycystic ovarian syndrome (PCOS), a condition associated with high testosterone levels and insulin resistance, seem to be at increased risk of OSA.115
Sex Hormone, Pituitary, Parathyroid, and Adrenal Disorders and the Nervous System
2014, Aminoff's Neurology and General Medicine: Fifth EditionGender-Specific Differences in Patients with Obstructive Sleep Apnea–Hypopnea Syndrome
2013, Encyclopedia of Sleep