Cyclophosphamide-induced Late-onset Lung Disease

Kunio HAMADA; Sonoko NAGAI; Masanori KiTAICHI; Guang Jin; Michio SHIGEMATSU; Taishi NAGAO; Atsuyasu SATO; Michiaki MISHIMA

doi:10.2169/internalmedicine.42.82

Kunio HAMADA, Sonoko NAGAI, Masanori KiTAICHI, Guang Jin, Michio SHIGEMATSU, Taishi NAGAO, Atsuyasu SATO, Michiaki MISHIMA

Author information

Kunio HAMADA
The Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
Sonoko NAGAI
The Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
Masanori KiTAICHI
The Laboratory of Anatomic Pathology, Kyoto University Hospital
Guang Jin
The Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University
Michio SHIGEMATSU
The Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
Taishi NAGAO
The Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
Atsuyasu SATO
The Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
Michiaki MISHIMA
The Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

Keywords: cyclophosphamide, late-onset, pulmonary fibrosis, restrictive disorder, elastosis, breast cancer

JOURNAL FREE ACCESS

2003 Volume 42 Issue 1 Pages 82-87

DOI https://doi.org/10.2169/internalmedicine.42.82

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Abstract

Wereport the case of a 58-year-old woman who was considered to have died of cyclophosphamide (CPA)-induced late-onset lung disease. She underwent a right-sided mastectomy due to breast cancer at the age of 50 followed by daily administration of 50 mg CPA and 20 mg tamoxifen for 2 years. A refractory cough and dyspnea began at the age of 56. Chest radiographs revealed diffuse infiltrates and pleural thickening. Her vital capacity was markedly reduced. Corticosteroid therapy was ineffective. The disease rapidly progressed with occasional episodes of pneumothoraces to her death. Postmortem examination revealed pulmonary fibrosis with marked elastosis.
(Internal Medicine 42: 82-87, 2003)

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