Chest
Clinical InvestigationsPulmonary Vascular Hemodynamics in Chronic Lung Disease Patients with and without Oxyhemoglobin Desaturation During Sleep
Section snippets
MATERIALS AND METHODS
Forty-nine male veterans with chronic lung disease were recruited from the Houston Veterans Administration Medical Center chest medicine clinics to participate in this study. None had clinical evidence of chronic cor pulmonale. None showed substantial left ventricular dysfunction by gated equilibrium radionuclide ejection fraction (<45 percent = dysfunction). Chronic lung disease was defined by a history of cough, exertional dyspnea, or wheezing, spirometry consistent with irreversible
Pulmonary Function and Gas Exchange
The two groups did not vary with respect to age, percentage of ideal body weight, RVEF, LVEF (Table 1), or parameters of pulmonary function including spirometry, body plethysmographic measurements, and DCO (Table 2). Hemoglobin was significantly higher in the NOD group (15.2 vs 14.4 g/dL). The RBC mass corrected for predicted was normal for both groups. However, when corrected for body weight, the NOD group value was higher.
There were several important differences between the groups with regard
DISCUSSION
The goal of this study was to determine whether there were differences in parameters of cardiopulmonary function between two subsets of patients with chronic lung disease. Since the predominant lung disease pattern was obstructive, FEV1 was chosen as a parameter for matching groups. Numerous studies show that in obstructive lung disease, FEV1 correlates with clinical symptomatology, survival,16, 17, 18 and to some degree, pulmonary hemodynamics.19
Patients who had restrictive components along
REFERENCES (34)
- et al.
Arterial blood gases and pH during sleep in chronic obstructive pulmonary disease
Am J Med
(1975) - et al.
Nocturnal pulmonary hypertension in patients with chronic obstructive pulmonary disease
Chest
(1979) - et al.
Cardiopulmonary hemodynamics during sleep in subjects with chronic obstructive pulmonary disease: the effect of short and long term oxygen
Chest
(1984) Clinical hypoxia: causes, consequences, and correction
Lancet
(1978)- et al.
The origins of cor pulmonale, a hypothesis
Chest
(1979) - et al.
Factors affecting prognosis in emphysema
Dis Chest
(1964) - et al.
Routine pulmonary function studies as a key to the status of the lesser circulation in chronic obstructive pulmonary disease
Am J Med
(1971) - et al.
Nocturnal oxyhemoglobin desaturation in COPD patients with arterial oxygen tensions above 60 torr
Chest
(1987) - et al.
Course of pulmonary hemodynamics in patients with chronic obstructive pulmonary disease
Chest
(1979) Structure and function in pulmonary hypertension
Chest
(1986)
Oximeter studies on patients with chronic obstructive emphysema, awake and during sleep
N Engl J Med
Studies of oxygenation during sleep in patients with interstitial lung disease
Am Rev Respir Dis
Nonapneic mechanisms of arterial oxygen desaturation during rapid-eye-movement sleep
J Appl Physiol Environ Exer Physiol
Transient hypoxemia during sleep in chronic bronchitis and emphysema
Lancet
Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease
Ann Intern Med
Long-term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema
Lancet
A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects
Cited by (0)
Supported by the General Research Service, Veterans Administration and in part by a grant from Oximetrix, Inc, Mountain View, CA. Computational assistance was provided by the CLINFO project, funded by the Division of Research Resources of the NIH under grant No RR-00350.
Manuscript received August 8; revision accepted October 31.