Chest
Original Research: Sleep MedicineRelationship Between Upper Airway and Inspiratory Pump Muscle Force in Obstructive Sleep Apnea
Section snippets
Subjects
Ninety-four consecutive patients (52 men and 42 women) attending the Respiratory Sleep Disorders Clinic at Sir Charles Gairdner Hospital for overnight polysomnography were recruited into the study (Table 1). Subjects were excluded from participation if they had been or were being treated with continuous positive airway pressure, had undergone previous surgical treatment for sleep-disordered breathing, or if they had neuromuscular or pulmonary disease. This study was approved by the Sir Charles
Subjects
A total of 94 subjects were studied (Table 1). As a group, they were obese (BMI, 32 ± 8 kg/m2) and had moderate OSA (AHI, 25 ± 30/h). Compared to female subjects, male subjects were taller and had greater neck circumference. BMI, AHI, neck circumference, and cricomental space were greater in subjects with OSA vs subjects without OSA (Table 2). On average, subjects slept for 5.8 ± 1.7 h, had an average sleep efficiency of 76.1 ± 12.6%, and spent 2.3 ± 3.4% of the night in stage 1 sleep, 66.8 ±
Discussion
This study measured the strength of UA dilator and inspiratory pump muscles in individuals with and without OSA, and examined the potential for measurements of the relative force-generating capacity of these muscles to identify individuals who may be susceptible to UA collapse during sleep (ie, OSA). The major findings of the study were as follows: (1) in both male and female subjects and when all subjects were considered as a single group, TP force was greater when measured supine than seated;
ACKNOWLEDGMENT
We wish to thank the technical staff of the West Australian Sleep Disorders Research Institute for their support.
References (24)
- et al.
Muscle fibre type and habitual snoring
Lancet
(1991) - et al.
Mortality and apnea index in obstructive sleep apnea: experience in 385 male patients
Chest
(1988) - et al.
Pathogenesis of upper airway occlusion during sleep
J Appl Physiol
(1978) - et al.
Sleep-related breathing disorders in amyotrophic lateral sclerosis
Monaldi Arch Chest Dis
(2003) - et al.
Physiologic, metabolic, and muscle fiber type characteristics of musculus uvulae in sleep apnea hypopnea syndrome and in snorers
J Clin Invest
(1995) - et al.
Patients with obstructive sleep apnea exhibit genioglossus dysfunction that is normalized after treatment with continuous positive airway pressure
Am J Respir Crit Care Med
(1999) - et al.
Upper airway muscle inflammation and denervation changes in obstructive sleep apnea
Am J Respir Crit Care Med
(2004) - et al.
Tongue protrusion strength and fatigability: relationship to apnoea/hypopnoea index and age
J Sleep Res
(2000) - et al.
Influence of excessive weight loss after gastroplasty for morbid obesity on respiratory muscle performance
Thorax
(1998) - et al.
Effects of posture on respiratory mechanics in obesity
J Appl Physiol
(1995)
Compliance of the respiratory system and its components in health and obesity
J Appl Physiol
Tongue protrusion force and fatigability in male and female subjects
Eur Respir J
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Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).
The authors have no conflict of interests with any part of this study to disclose.
This study was funded, in part, by National Health and Medical Research Council (Australia) Grant No. 303218. Dr. Eastwood was supported by a National Health and Medical Research Council (Australia) R. Douglas Wright Fellowship (No. 294404).
Ms. Shepherd, Dr. Eastwood, and Dr. Hillman contributed to the study conception, design, data interpretation, and preparation and revision of the manuscript. Ms. Shepherd, Ms. Jensen, and Ms. Maddison were primarily responsible for data collection.
This article was submitted through the West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia.