Chest
Original Research: Lung FunctionA Statistical Rationale for the Use of Forced Expired Volume in 6 s
Section snippets
Materials and Methods
Spirometry was performed in 4,827 subjects recruited for the FHS, a community-based, multicenter study5 of genetic and nongenetic determinants of coronary heart disease. Data were collected at four field centers (Framingham, MA; Minneapolis, MN; Forsyth County, NC; and Salt Lake City, UT). Spirometric data were obtained by trained technicians using the 1987 ATS standards.6 Each participant performed five to eight spirometric maneuvers using a water-sealed spirometer connected to a linear
Results
There were 4,827 FHS participants; 3,539 subjects were entered into group 1 to analyze the FEVx variability. Group 1 contained spirometry tests for all individuals who completed at least three maneuvers with at least 10 s of exhalation, and data were analyzed up to 12 s. Some of the tests did not meet the ATS reproducibility requirement of 200 mL (n = 141) but were included so that no systemic bias was introduced in the estimates of the FEVx variability. Average spirometric data for these
Discussion
Reference value comparisons require both biological and technical comparability between the person being tested and the reference values.10 Reducing intraindividual variation in spirometry measures will create closer alignment between reference populations and should decrease errors in clinical classification: first, by ensuring that each measured value more precisely represents the individual being tested; second, by more accurately placing an individual’s measurements above or below the LLN.
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Cited by (18)
FEV1/FEV6 is effective as a surrogate for FEV1/FVC in the diagnosis of chronic obstructive pulmonary disease
2021, Indian Journal of TuberculosisCitation Excerpt :A meta-analysis by Jing et al. concluded that FEV1/FEV6 is a sensitive and specific test for the diagnosis of airway obstruction and can be used as a valid alternative for the FEV1/FVC in the diagnosis of airway obstruction.32 Most of the studies done were retrospective in nature and analysed spirometry data of studies with different aims and objectives to start with.5,10,13–18 While accessing the correlation between two ratios either two separate efforts or instruments or the different operators were used by several studies.
Correlation and Agreement of Handheld Spirometry with Laboratory Spirometry in Allogeneic Hematopoietic Cell Transplant Recipients
2016, Biology of Blood and Marrow TransplantationCitation Excerpt :Although not routinely used for interpretation by most practitioners, FEV6 is recorded by standard laboratory spirometers provided that the patient exhales to 6 seconds. FEV6 is considered is an acceptable surrogate for FVC [32] and has been validated in patients with obstructive lung disease [33-35]. Recording FEV6 is considered to be more reproducible and less physically demanding than recording FVC [17], although these were not the specific reasons that we used FEV6 in our study.
Should FEV<inf>1</inf>/FEV<inf>6</inf> replace FEV/FVC ratio to detect airway obstruction? a metaanalysis
2009, ChestCitation Excerpt :Study population was adult patients in four studies. The other seven study populations came from community: one study29 included current smokers, one study26 included workers, and the other studies30,31,34,35,37 were of the adult general population. The clinical characteristics of these studies along with QUADAS scores are outlined in Table 1.
Simplified spirometry: is it that simple?
2009, Revue des Maladies Respiratoires
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).
The authors have no conflicts of interest to disclose.
†The Family Heart Study is a National Institutes of Health-funded multicenter study.