Chest
Clinical Investigations PULMONARY FUNCTION TESTINGAirway Narrowing Measured by Spirometry and Impulse Oscillometry Following Room Temperature and Cold Temperature Exercise
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Subjects
Twenty-two physically active individuals with probable EIB were recruited to participate in this study (mean age ± SD, 25.2 ± 8.4 years; height, 1.71 ± 0.08 m; weight, 74.7 ± 15 kg; 10 men and 12 women). The Institutional Review Board of Marywood University approved the study protocol, and subjects provided written informed consent for participation. Eight subjects reported using an inhaled β2-agonist prior to exercise, one subject was receiving salmeterol, one subject was receiving fluticasone
Baseline Lung Function
Individual and mean resting lung function values from IOS and spirometry are presented in Table 1. Resting FVC values were normal, ranging from 81.67 to 135.59% of predicted values. One subject demonstrated below-normal resting FEV1 (78.6% of predicted value). Five of 22 subjects (22.7%) demonstrated < 70% of predicted FEF50, suggestive of mild airflow limitation and small-airway involvement. Significant correlations were identified between resting spirometry and IOS values (p < 0.05): FVC and
Discussion
In this study, we compared airway responses following randomly assigned RTEX and CTEX challenges and examined whether resting and postchallenge spirometry variables correlated with resting and postchallenge IOS variables. Six minutes of exercise while breathing dry medical-grade bottled air was a suitable challenge for inducing the EIB response.25 Heart rate during exercise and the amount of work performed indicated that the challenges were at an intensity sufficient to provoke EIB,26 and
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This study was supported by the American College of Sports Medicine Foundation, and performed at the Marywood University Human Performance Laboratory.
The views, opinions, and findings contained in this report are those of the authors and should not be construed as an official Marywood University position.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).