Chest
Clinical InvestigationsCopdExercise Capacity Deterioration in Patients With COPD: Longitudinal Evaluation Over 5 Years
Section snippets
Subjects
We recruited 137 consecutive male outpatients with moderate-to-very-severe COPD, as defined by the American Thoracic Society and European Respiratory Society 2004 guidelines.1 These participants consisted of 131 patients enrolled in a previous study6 investigating the relationship between the baseline measures and 5-year mortality between September 1995 and January 1997, and 6 patients who were added from February 1997 to April 1997. The entry criteria included the following: (1) a smoking
Results
The baseline characteristics of the 137 male patients are shown in Table 1. Their average age was 69.0 ± 6.6 years, and postbronchodilator FEV1 was 45.9 ± 15.4% predicted. When the patients were classified according to their COPD severity based on postbronchodilator FEV1, 53 patients (39%) had moderate COPD (FEV1 ≥ 50 to < 80% predicted), 59 patients (43%) had severe COPD (FEV1 ≥ 30 to < 50% predicted), and 25 patients (18%) had very severe COPD (FEV1 < 30% predicted).
Changes in peak o2,
Discussion
We found clear evidence of a measurable and progressive deterioration in exercise capacity in patients with moderate-to-very-severe COPD. To our knowledge, this is the first published study on COPD to demonstrate a longitudinal decline in laboratory exercise capacity evaluated by peak o2 on progressive cycle ergometry prospectively over 5 years. We previously reported that peak o2 was the most significant predictor of mortality among several indexes evaluating COPD,6 and we could
References (36)
- et al.
Withdrawal from treatment as an outcome in the ISOLDE study of COPD
Chest
(2003) - et al.
A comparison of the effects of salbutamol and ipratropium bromide on exercise endurance in patients with COPD
Chest
(2003) - et al.
Relationship between different indices of exercise capacity and clinical measures in patients with chronic obstructive pulmonary disease
Heart Lung
(2002) - et al.
The relationship of the 6-min walk test to maximal oxygen consumption in transplant candidates with end-stage lung disease
Chest
(1995) - et al.
Physiologic responses to incremental and self-paced exercise in COPD: a comparison of three tests
Chest
(2004) - et al.
How should we measure function in patients with chronic heart and lung disease?
J Chron Dis
(1985) - et al.
Longitudinal changes in airflow limitation and airway hyperresponsiveness in patients with stable asthma
Ann Allergy Asthma Immunol
(2002) - et al.
Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
Eur Respir J
(2004) - et al.
The natural history of chronic airflow obstruction
BMJ
(1977) - et al.
The course and prognosis of different forms of chronic airways obstruction in a sample from the general population
N Engl J Med
(1987)
Extrapulmonary effects of chronic obstructive pulmonary disease
Curr Opin Pulm Med
Health status measurement in chronic obstructive pulmonary disease
Thorax
Analysis of the factors related to mortality in chronic obstructive pulmonary disease: role of exercise capacity and health status
Am J Respir Crit Care Med
The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
N Engl J Med
The 6-min walk distance: change over time and value as a predictor of survival in severe COPD
Eur Respir J
Statistical methods
Eur Respir J
Standardization of spirometry, 1994 update
Am J Respir Crit Care Med
The predicted values of pulmonary function testing in Japanese [in Japanese]
Jpn J Thoracic Dis
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Physiological and perceptual responses to exercise according to locus of symptom limitation in COPD
2020, Respiratory Physiology and NeurobiologyEffect of exercise capacity on perception of dyspnea, psychological symptoms and quality of life in patients with chronic obstructive pulmonary disease
2020, Heart and LungCitation Excerpt :Exercise capacity is a very important parameter being used recently to determine the prognosis and response to therapeutic interventions.22 Just like FEV1, walking distance also decreases in time in COPD patients.21–24 However, this decrease in walking distance is independent from respiratory functions.21