Chest
Clinical InvestigationsPULMONARY FUNCTION TRAITSA Single Measure of FEV1 Is Associated With Risk of Asthma Attacks in Long-term Follow-up
Section snippets
Populations
We analyzed data from two large population-based cohorts, details of which have been published elsewhere.11121314 The Netherlands cohort, a longitudinal study of host factors and environmental determinants of chronic obstructive lung disease, was initiated in 1965 with a random sample of residents in Vlagtwedde and Vlaardingen, the Netherlands. From this sample, those aged (at the time of the 1965 study) 40 to 44 years from Vlagtwedde and 40 to 54 years from Vlaardingen were combined with a
Results
The original Netherlands and US cohorts included 4,692 subjects and 8,842 subjects, respectively. The current analysis was limited to the 195 subjects in the Netherlands cohort and the 698 subjects in the US cohort who reported an “asthma attack” (one or more attacks of wheezing and shortness of breath), at some time during the follow-up and who had a cumulative smoking history of ≤ 10 pack-years.
Table 1shows baseline characteristics of the individual subjects included in the current analysis.
Discussion
The NAEPP has endorsed the use of objective measures of lung function to assign a severity rating to patients with asthma.2 The purpose of such a severity rating is to guide asthma therapy, and the major assumption underlying it is that different categories of FEV1% predicted suggest different risks of adverse disease outcomes. Despite its intuitive appeal, little data exist in the literature to support this assumption. Our study suggests that in two separate cohorts, a single measure of FEV1
References (42)
- et al.
Asthma control versus asthma severity
J Allergy Clin Immunol
(1996) - et al.
Lack of correlation of symptoms with specialist-assessed long-term asthma severity
Chest
(1999) Course and prognosis of patients with chronic airways obstruction
Chest
(1980)- et al.
Follow-up of asthma from childhood to adulthood: influence of potential childhood risk factors on the outcome of pulmonary function and bronchial responsiveness in adulthood
J Allergy Clin Immunol
(1994) - et al.
FEV1is associated with risk of asthma attacks in pediatric population
J Allergy Clin Immunol
(2001) - et al.
Fluticasone propionate improves quality of life in patients with asthma requiring oral corticosteroids
Ann Allergy Asthma Immunol
(1996) - et al.
Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children
Respir Med
(1994) - et al.
High does nebulized steroid in the treatment of chronic steroid-dependent asthma
Respir Med
(1992) - et al.
Efficacy and safety of loratadine plus pseudoephedrin in patients with seasonal allergic rhinitis and mild asthma
J Allergy Clin Immunol
(1997) - et al.
Poverty, race, and medication use are correlates of asthma hospitalization rates: a small area analysis in Boston
Chest
(1995)
Guidelines for the management of asthma: a summary
BMJ
National Asthma Education and Prevention Program Expert Panel. Clinical practice guidelines: expert panel report 2; guidelines for the diagnosis and management of asthma.1997,1-153 National Heart, Lung, and Blood Institute. Bethesda, MD: publication No. 97–4051
Global strategy for asthma management and prevention: NHLBI/WHO workshop report.
Prospective study of hospitalization for asthma: a preliminary risk factor model
Am J Respir Crit Care Med
Site and nature of airway obstruction in chronic obstructive lung disease
N Engl J Med
Nonreversible airflow obstruction in life-long nonsmokers with moderate to severe asthma
Eur Respir J
Effects of sulfur oxides and respirable particles on human health: methodology and demography of populations in study
Am Rev Respir Dis
Longitudinal and cross-sectional estimates of pulmonary function decline in never-smoking adults
Am J Epidemiol
The relationship of nonspecific bronchial responsiveness to respiratory symptoms in a random population sample
Am Rev Respir Dis
Decreases in VC and FEV1with time: indicators for effects of smoking and air pollution
Bull Eur Physiopathol Respir
Committee on research into chronic bronchitis; instructions for the use of the questionnaire on respiratory symptoms
Cited by (133)
Impact of obesity in asthma: Possible future therapies
2024, Allergology InternationalGEMA 5.3. Spanish Guideline on the Management of Asthma
2023, Open Respiratory ArchivesBronchial asthma
2022, Medicine (Spain)The 5T approach in asthma: Triple Therapy Targeting Treatable Traits
2022, Respiratory MedicineExacerbation-Prone Asthma: A Biological Phenotype or a Social Construct
2021, Journal of Allergy and Clinical Immunology: In PracticeStrategies for prescription of inhaled corticosteroids in mild-to-moderate asthma
2021, Revue des Maladies Respiratoires
Funding was provided by AstraZeneca Pharmaceuticals, 1-K08 HL03919–01; and National Heart, Lung and Blood Institute, National Institutes of Health grant HL027427.