Chest
Clinical InvestigationsPulmonary Function TestsSevere Gastroesophageal Reflux Is Associated With Reduced Carbon Monoxide Diffusing Capacitya
Section snippets
Samples and Selection Criteria
Data on 147 consecutive patients who presented for weight loss surgery were assessed retrospectively. Patients are considered for obesity surgery if they present with a body mass index (BMI) of > 35 kg/m2 and are experiencing significant medical, physical, or psychosocial disabilities.
Preoperatively, a full medical history was taken and a physical examination was performed. Information on GER included history, previous investigations, and medication usage. Patients completed a questionnaire
Results
Data from 147 consecutive obese patients (BMI range, 31.7 to 70 kg/m2) were analyzed retrospectively. Patient demographics are in Table 1. The patients with grade 3 GER were significantly older (p = 0.006).
The group with grade 3 GER (n = 21) did not have an increased prevalence of current smoking (Table 1), although there was a difference between groups in the number of pack-years previously smoked (p < 0.001). This increase in pack-years smoked was present in the grade 2 (mild GER) group only
Discussion
The principle finding of this study was that severe GER, defined by the findings of pH monitoring and/or gastroscopy, is associated with a reduction in gas diffusion. This effect was not due to differences in obesity, weight distribution, spirometric function, or lung volumes. Furthermore, there did not appear to be any other relevant medical history to account for these gas exchange abnormalities.
The current series is the largest to date assessing GER and diffusing capacity. No previous
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