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Preliminary ReportsInterferon Therapy Induces the Improvement of Lung Function by Inhaled Corticosteroid Therapy in Asthmatic Patients With Chronic Hepatitis C Virus Infection*: A Preliminary Study
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Materials and Methods
Forty-eight HCV-positive patients with a diagnosis of asthma according to the American Thoracic Society guidelines9 were recruited into this study. These patients were randomly selected from a region (Osaka City, Japan) with an extraordinarily high incidence of chronic HCV infection. Eight patients were lost during the follow-up period as a result of cardiovascular disease, hepatocellular carcinoma, or transfer to another hospital. Anti-HCV antibody was measured with a first-generation or
Results
The clinical characteristics of the 40 asthmatic patients with chronic HCV infection are shown in Table 1. The three groups were well-matched with respect to age and baseline lung function. However, increased levels of aspartate aminotransferase and alanine aminotransferase were found in all three groups. After the 4-week run-in period, there was no significant difference in either prebronchodilator or postbronchodilator FEV1 values among the three groups. After 6 weeks of BDP therapy, there
Discussion
In this study, we found that inhaled BDP therapy did not significantly improve prebronchodilator and postbronchodilator FEV1 values after 6 weeks of BDP therapy in patients in any of the three groups. However, previous studies have reported1112 that the baseline value of FEV1 after inhaled steroid therapy markedly improved in steroid-naive asthmatic patients. Moreover, prebronchodilator and postbronchodilator FEV1 values were significantly higher 1 year after the end of IFN therapy than after 6
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This work was supported by a grant-in-aid for Scientific Research (No. 13670611) from the Ministry of Education, Science, and Culture, Japan.