Chest
Clinical InvestigationsAsthmaVascular Involvement in Exercise-Induced Airway Narrowing in Patients With Bronchial Asthma
Section snippets
Subjects
The normal controls consisted of 12 subjects (mean age, 32.9 years; mean FEV1, 107.3%). All normal control subjects were healthy, lifelong nonsmoking volunteers who had no history of lung disease. All asthmatic patients satisfied the American Thoracic Society criteria for asthma.5 The clinical characteristics of these patients are shown in Table 1. The 25 asthmatics included in this study were all nonsmokers. Methacholine inhalation challenge testing was performed for all asthmatics. All
Results
Thirteen EIB-positive asthmatics and 12 EIB-negative asthmatics were well matched with respect to age, baseline lung function, and hyperreactivity to methacholine (Table 1). There were also no significant differences in temperature or humidity during the exercise test between EIB-positive asthmatics and EIB-negative asthmatics. However, the percentage of eosinophils and the concentration of ECP in induced sputum in EIB-positive asthmatics (% eosinophils, 20.6 ± 7.1%; ECP, 871 ± 187 ng/mL) were
Discussion
In the present study, higher levels of airway vascular permeability index were found in EIB-positive asthmatics than in EIB-negative asthmatics and normal control subjects. Moreover, there was a significant correlation between airway vascular permeability index and NO levels in induced sputum, the production of which was markedly increased in asthmatics. The role of excessively produced NO, if any, in the pathogenesis of bronchial asthma is under active investigation, and NO is known to be one
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Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects
2019, Journal of Allergy and Clinical ImmunologyExercise-induced bronchoconstriction update—2016
2016, Journal of Allergy and Clinical ImmunologyThe effect of mouth breathing on exercise induced fall in lung function in children with allergic asthma and rhinitis
2016, International Journal of Pediatric OtorhinolaryngologyCitation Excerpt :Based on FENO level, which is a quantitative, noninvasive and safe method of measuring eosinophilic airway inflammation, children with asthma can be prescreened into a group with high FENO, indicating the need for EIB testing or into a group with near normal FENO for whom EIB is unlikely. Kanazawa et al. showed thatexcessive production of NO in the airways correlates with the severity of EIB in asthmatic patients so assessment of FENO values could lead to an increased understanding of individual features of asthma (phenotype) and the need for prevention and treatment of EIB [24]. Children in our study had in both groups comparative FENO values higher than normal (mean > 40 ppb), thus indicating the need for EIB testing in most of them.
Asthma, physical exercise and oxidative stress: A review of literature
2014, Fisioterapia
Supported by grant-in-aid for Scientific Research (13670611) from the Ministry of Education, Science and Culture, Japan.