Chest
Clinical InvestigationsAsthmaElevated Concentrations of Exhaled Hydrogen Peroxide in Asthmatic Patients
Section snippets
Patients
Seventy patients (20 men and 50 women) with unstable, steroid-naive, atopic asthma (age range, 18 to 62 years; median age, 33 years) were examined at the outpatient department of the Hospital Therapeutic Clinic of Pavlov Medical University, St. Petersburg, Russia. They had nocturnal wheezing and daily asthma symptoms. Asthma was diagnosed according to American Thoracic Society criteria.12 Diagnosis was based on clinical history, reversibility of FEV1 > 15%, and diurnal variability of peak
Results
The concentrations of H2O2 in expired breath condensate and ECP in serum in asthmatic patients and normal subjects are shown in Table 1. The concentrations of exhaled H2O2 and ECP in serum were significantly elevated in asthmatic patients compared to normal subjects. There was a negative correlation between expired H2O2 concentration and FEV1 (r = − 0.45; n = 70; p < 0.001; Fig 1) and between H2O2 and PC20 (rs = − 0.40; n = 28; p < 0.05; Fig 2), and a positive correlation between expired H2O2
Discussion
The mean concentration of expired H2O2 was elevated in untreated asthmatic patients in comparison to levels in normal subjects. Most of the asthmatic patients (94%) had an increased level of H2O2. This may indicate an enhanced production of oxidants and/or decreased antioxidant capacity of asthmatic airways. However, the concentrations of H2O2 in four patients with asthma were similar to those in healthy subjects, perhaps reflecting a higher concentration of antioxidants in these patients.9
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Supported in part by a research grant from MacLab (Melbourne, Australia).