Chest
Clinical InvestigationsDiffuse Lung DiseaseBronchiolitis Obliterans in the 1990s in Korea and the United States
Section snippets
Materials and Methods
The medical records of children who had received diagnoses of BO between 1990 and 1999 at two university medical centers in Korea (ie, Inje University Sanggye Paik Hospital, Seoul, South Korea, and Seoul National University Hospital, Seoul, South Korea) and two university medical centers in the United States (ie, University of Colorado Health Sciences Center, Denver, CO, and Washington University Hospital, St. Louis, MO) were retrospectively reviewed.
Patients were included in the study if they
Clinical Presentation
A total of 31 children with BO were evaluated. Demographic data are presented in Table 1. The large number of Asian children in this group reflects a clustering of cases in Korea due to an adenovirus type 7 epidemic in 1996 and a Mycoplasma epidemic in 1995. In our series, a male predominance was noted. The mean age at the onset of symptoms was 46.4 months (age range, 7 to 183 months). The mean age at the time of diagnosis was 70.3 months (age range, 10 to 224 months). The mean duration of
Discussion
Our data demonstrate that BO in children is less severe than it has been known to be in the past and that the mortality rate has declined over the past decade. This could be related primarily to the use of HRCT for accurate diagnosis and the availability of pediatric lung transplantation.
To our knowledge, this is the largest series of pediatric BO patients reported to date. In contrast to older studies that utilized bronchography, ventilation-perfusion scans, and lung biopsies for diagnosis,
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Cited by (0)
This study was supported in part by a Clinician Scientist Grant awarded in 1998 to Dr. Chang Keun Kim by Inje University, Korea, and by a year 1999 Brain Korea 21 project for Medicine, Dentistry, and Pharmacy.