Chest
Clinical InvestigationsSleep and BreathingPlasma Homocysteine Levels in Obstructive Sleep Apnea: Association With Cardiovascular Morbidity
Section snippets
Participants
We investigated fasting levels of homocysteine in a total of 345 male participants. These included three groups of OSA patients: (1) OSA patients with IHD (IHD-OSA; n = 49), of whom 21 patients had a history of myocardial infarction, 3 patients had a history of cerebrovascular accident, and 1 patient had a history of peripheral vascular disease); (2) OSA patients with hypertension only (HT-OSA; n = 61), defined as either having a history of antihypertensive treatment or BP > 140/90 mm Hg (1
Results
The demographic, clinical, and biochemical data of the five groups are presented in Table 1, Table 2. Overall, the three OSA groups were of similar severity, with mean AHI and minimum oxygen saturation varying from 33.74 to 30.1 and from 85.09 to 79.95%, respectively, with large variability within groups. The five groups were statistically significantly different in age and BMI and had a different prevalence of diabetes mellitus. In addition, they had statistically significant different
Discussion
The major finding of the present study is that the IHD-OSA group had significantly higher homocysteine levels than the IHD-only group after adjustment for major potential confounding factors. Homocysteine levels in the IHD-OSA group were also higher than those of the HT-OSA and OSA-only groups, as well as the CON group. Furthermore, the HT-OSA group had comparable levels of homocysteine to the IHD-only group.
In comparison with literature data on large-scale epidemiologic studies in nonselected
Acknowledgment
We are grateful to J. Selhub and M.R. Nadeau for performing the B6 determination and the HPLC determination for homocysteine quality control. We are grateful to the Technion Sleep Disorders Center staff for their help, and to Ms. Paula Herer who carried out the statistical analysis.
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This study was supported in part by a grant from the Ministry of Health to Drs. L. Lavie and P. Lavie.