Chest
Clinical InvestigationsCOPDDistribution of Muscle Mass and Maximal Exercise Performance in Patients With COPD
Section snippets
Subjects
Thirty-eight ambulatory male patients with COPD were recruitedto participate in this study. The criteria for diagnosis of COPD werebased on the standards of the American Thoracic Society.14The entry criteria included the following: (1) clinical diagnosis of, COPD; (2) clinically stable condition (no recent infection or cardiaccomplaints); (3) absence of other pathologic conditions, includingneuromuscular, metabolic, and malignant disease; and (4) not receivingoral corticosteroids. All patients
Anthropometric and Pulmonary Function Data
Anthropometric characteristics and pulmonary function data of thetwo patient groups are described in Table 1. There was no significant difference inage and height, although the percentage of IBW and body mass index werestatistically different between the two groups. VC, FEV1, and MVV in group B were significantly lowerthan those in group A, while RV/TLC and, Paco2 were significantly higher ingroup B. Dlco and Pao2showed no significant difference between the two groups.
Distribution of LBM
The total LBM and
Discussion
In the present study, we measured LBM by DXA and assessed itseparately in arms, legs, and trunk. It was shown that asignificant reduction of LBM, expressed as a percentage of IBW in eachregion, was present in patients with severe airflow limitation comparedto patients with mild-to-moderate airflow limitation.
DXA has been validated against independent methods, includingγ-neutronactivation model, total body potassium, andhydrodensitometry, and is becoming one of the reference methods forbody
References (26)
- et al.
Body composition by bioelectrical impedance analysis compared with deuterium dilution and skinfold anthropometry in patients with chronic obstructive pulmonary disease
Am J Clin Nutr
(1991) - et al.
Relationship between respiratory muscle strength and lean body mass in men with COPD
Chest
(1995) - et al.
Body composition analysis by dual energy x-ray absorptiometry and exercise performance in underweight patients with COPD
Chest
(1999) - et al.
Dual-energy x-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition
Am J Clin Nutr
(1990) - et al.
Body composition by x-ray absorptiometry and bioelectrical impedance in chronic respiratory insufficiency patients
Nutrition
(1997) - et al.
Prevalence and characteristics of nutritional depletion in patients with stable COPD eligible for pulmonary rehabilitation
Am Rev Respir Dis
(1993) - et al.
Nutritional state and exercise performance in patients with chronic obstructive lung disease
Thorax
(1989) - et al.
Peripheral muscle weakness in patients with chronic obstructive pulmonary disease
Am J Respir Crit Care Med
(1998) - et al.
Strength and cross-sectional area of human skeletal muscle
J Physiol
(1983) - et al.
Peripheral muscle weakness contributes to exercise limitation in COPD
Am J Respir Crit Care Med
(1996)
Muscle strength, symptom intensity and exercise capacity in patients with cardiorespiratory disorders
Am J Respir Crit Care Med
Metabolic enzyme activity in the quadriceps femoris muscle in patients with severe chronic obstructive pulmonary disease
Am J Respir Crit Care Med
Oxidative capacity of skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD
Am J Respir Crit Care Med
Cited by (34)
Dual-energy X-ray absorptiometry body composition in patients with secondary osteoporosis
2016, European Journal of RadiologyCitation Excerpt :Total body LM assessed by DXA was reported to be associated with respiratory muscle strength in patients with chronic obstructive pulmonary disease (COPD) [59]. Also, it was founded that lower limb LM was a significant predictor of maximal exercise performance in patients with mild-to-moderate airflow limitation, but not in patients with severe airflow limitation who presented a significative reduction in lower limb LM [59]. Even though all these DXA body composition clinical applications, as well as several others, were not included in the ISCD Position Paper, they are of interest for possible future applications.
Diagnostic and Therapeutic Challenges in Patients With Coexistent Chronic Obstructive Pulmonary Disease and Chronic Heart Failure
2007, Journal of the American College of CardiologyCitation Excerpt :Muscle atrophy contributes to muscle fatigue during exercise, which leads patients with CHF or COPD to discontinue exercising although they have not exhausted their cardiac or pulmonary reserve (30,31). Peak oxygen uptake is linearly related to SM mass in patients with CHF and or COPD (32–34). As the disease progresses, SM atrophy worsens and patients with CHF or COPD become increasingly symptomatic (Fig. 3).
Body composition in patients with chronic hypercapnic respiratory failure
2006, Respiratory MedicineThe impact of severe acute respiratory syndrome on the physical profile and quality of life
2005, Archives of Physical Medicine and RehabilitationCitation Excerpt :The 6-minute walk distance covered by our post-SARS patients (597.9m) was greater than the distance reported in studies of patients with COPD (473.5m). 24 Also, the predicted V̇o2max in SARS patients who required ICU admission was 36mL·kg−1·min−1, whereas for those recovering from ARDS after intensive care was 24mL·kg−1·min−1, 25 and for those with COPD was as low as 12.4mL·kg−1·min−1. 26 The decrease in cardiorespiratory and musculoskeletal function in patients who were hospitalized for a mean of 3 weeks was not surprising.
A randomised controlled trial of the effectiveness of an exercise training program in patients recovering from severe acute respiratory syndrome
2005, Australian Journal of Physiotherapy