Chest
Clinical InvestigationsCOPDUpregulation of Gelatinases A and B, Collagenases 1 and 2, and Increased Parenchymal Cell Death in COPD
Section snippets
Study Population
We studied the expression and localization of immunoreactive MMP-1, MMP-2, MMP-8, MMP-9, and MMP-13 in paraffin-embedded lung tissues collected from 10 male individuals with COPD (group 1). Seven of them were obtained from autopsies of patients with prolonged and terminal lung disease (mean age ± SD, 66.8 ± 5.5 years), while the other three derived from lung volume reduction surgery (ages, 59, 56, and 55 years). Male individuals who died from causes other than lung diseases were used as control
Results
Mean ( ± SD) values of age, smoking history, and lung functional characteristics are shown in Table 1. All patients were heavy smokers and displayed severe airflow limitation, but no statistical differences were found in the functional respiratory tests of both groups. On microscopic examination, lung tissues of group 1 exhibited varied, but usually severe, airway inflammation, goblet cell hyperplasia, and focal squamous metaplasia. In peripheral airways, variable degrees of wall inflammation,
Discussion
COPD is a chronic respiratory disorder characterized by slowly progressive airflow obstruction. It usually occurs in heavy smokers, and it is associated with variable degrees of bronchial inflammation and mucus gland hyperplasia, small airway inflammation and fibrosis, and emphysema. Inflammation in COPD is a central and complex pathologic process involving different immune and inflammatory cells, although the precise role of each of them in the pathogenesis is still controversial. According to
References (41)
- et al.
Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema
Cell
(1992) - et al.
The structural basis for the elastolytic activity of the 92-kDa and 72-kDa gelatinases
J Biol Chem
(1996) - et al.
Oxidative stress as a mediator of apoptosis
Immunol Today
(1994) - et al.
Collagenase and collagenase inhibitors in bronchoalveolar lavage fluids
Chest
(1991) - et al.
Gelatinases A and B are upregulated in lung rats by subacute hyperoxia: pathogenetic implications
Am J Pathol
(1998) The role of infection in COPD
Chest
(1998)- et al.
The collagen substrate specificity of human skin fibroblast
J Biol Chem
(1981) - et al.
H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloproteinase capable of degrading membrane collagen
J Biol Chem
(1988) - et al.
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
Cell
(1998) Course and prognosis in advanced disease
Official Statement of the American Thoracic Society, 1987: Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma
Am Rev Respir Dis
Elastases and emphysema: current assessment of the protease-antiprotease hypothesis
Am Rev Respir Dis
Emphysema: the first two centuries and beyond
Am Rev Respir Dis
Tobacco smoke-induced lung emphysema in guinea pigs is associated with increased interstitial collagenase
Am J Physiol
Matrix metalloproteinase expression and production by alveolar macrophages in emphysema
Am J Respir Crit Care Med
The effect of cigarette smoking on neutrophil kinetics in human lungs
N Engl J Med
Alveolar inflammation and its relation to emphysema in smokers
Am J Respir Crit Care Med
Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
Science
Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema
Lab Invest
Apoptosis and DNA damage in type 2 alveolar epithelial cells cultured from hyperoxic rats
Am J Physiol
Cited by (431)
Long-term e-cigarette aerosol exposure causes pulmonary emphysema in adult female and male mice
2023, Regulatory Toxicology and PharmacologyChronic obstructive pulmonary disease and emerging ER stress-related therapeutic targets
2023, Pulmonary Pharmacology and TherapeuticsEfferocytosis in lung mucosae: implications for health and disease
2022, Immunology Letters
This study was partially supported by PUIS-UNAM, and CONACYT Grant number F643-M9406.