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Clinical InvestigationsOsteoporosis and Lung Transplantation: A Prospective Study
Section snippets
Study Patients
All patients who underwent transplantation at the Toronto Hospital between June 12, 1996, and February 21, 1998, who survived a minimum of 6 months post-lung transplant were eligible for our study. Forty patients underwent transplantation during the study period, and 9 patients died within 6 months of transplantation. We were unable to obtain the pretransplant BMD on 3 of the 31 eligible patients (9.6%).
The BMD of the LS and FN of 28 patients was measured pretransplant (mean, 4.9 months prior
Results
The median age of the 28 patients (16 men and 12 women) enrolled in our study was 53.5 years (range, 21 to 67 years). Pretransplant demographics, broken down by underlying lung disease, are illustrated in Table 1.
Moderate to severe bone disease was evident pretransplantation. The mean (± SD) pretransplant BMD of the LS was 0.821 ± 0.168 g/cm2 with mean Z and T scores of −1.44 ± 1.5 and −1.72 ± 1.37, respectively. The mean pretransplant BMD of the FN was 0.632 ± 0.108 g/cm2 with mean Z and T
Discussion
Our study demonstrated a statistically significant drop in BMD at both the LS (4.76%) and the FN (5.3%) within 6 to 12 months posttransplantation, despite prophylactic treatment with vitamin D and calcium. The only other prospective study in this area, which was conducted by Ferrari et al18 with 12 patients (all treated with vitamin D and calcium alone), found a BMD loss of 4% at the LS within 3 to 6 months posttransplant, with no statistically significant loss at the FN. The drop in BMD in our
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