Chest
Clinical InvestigationsASTHMAEffect of Sputum Induction on Spirometric Measurements and Arterial Oxygen Saturation in Asthmatic patients, Smokers, and Healthy Subjects
Section snippets
Subjects
We selected a group of 14 patients (age range, 18 to 49 years) with bronchial asthma as defined by the American Thoracic Society.13 We included lifetime-nonsmoking patients with no respiratory infections or spontaneous asthma relapses in the 4 weeks before the study. Respiratory symptoms were controlled with inhaledβ 2-agonists on a daily basis or as required. Patients requiring steroids or sodium cromoglycate were excluded. Baseline FEV1 had to be > 60% of the predicted value. The presence of
Results
Subject characteristics are shown in Table 1. Asthmatic subjects showed significantly lower baseline FEV1 values than subjects with a history of smoking or healthy subjects (p < 0.05), and no differences were found among the three groups with respect to gender and age. During the sputum induction procedure, the most commonly reported side effects included slight nausea with retching and an unpleasant salty taste. No subject developed side effects sufficiently severe to require premature
Discussion
This study has shown a significant fall in Sao2 during the stated sputum-induction procedure for subjects with bronchial asthma, subjects with a history of smoking, and healthy subjects. Additionally, the study has confirmed that sputum production induced by inhaling hypertonic saline solution is well tolerated in subjects with mild-to-moderate bronchial asthma, subjects with a history of smoking, and healthy subjects.
In accordance with the safety protocol proposed by Wong and Fahy,9 we
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Cited by (25)
Improved sputum expectoration following a single dose of INS316 in patients with chronic bronchitis
2002, ChestCitation Excerpt :Because adverse events and a higher incidence rate of bronchoconstriction have been observed at the 180-mg dose of INS316, future studies of INS316 will evaluate doses only as high 100 mg. One should also note that the incidence of bronchoconstriction with the highest dose of INS316 is similar to that reported by others when hypertonic (3%) saline solution was used to induce sputum in smokers.19 Since this article was initially submitted, Tamaoki et al27 reported the results of a study of sputum induction comparing UTP with 3% hypertonic saline solution in healthy individuals and in patients with mild-to-moderate asthma.
Exhaled nitric oxide correlated with induced sputum findings in COPD
2001, ChestCitation Excerpt :In this study, 3% saline solution caused a significant fall in FEV1 that returned to near baseline values after albuterol. A recent publication34 showed that oxygen saturation, which we did not monitor, fell by a mean value of 6.0% in smokers during sputum induction. These findings led us to recommend precautionary measures when inducing sputum in COPD subjects.
Noninvasive measurement of airway inflammation using exhaled nitric oxide and induced sputum: Current status and future use
2000, Clinics in Chest MedicineCitation Excerpt :Subjects should stay in the laboratory until FEV1 returns to greater than 90% of baseline values, however. Castagnaro et al10 measured pulse oximetry during sputum induction, and reported a significant mean drop in oxygen saturation in asthmatic patients (6%), smokers (5.3%), and healthy subjects (6.0%). The mean (± SD) drop in FEV1 was not statistically different among the three groups.
Use of exhaled nitric oxide as readout for inhaled corticosteroid efficacy
2016, Inhaled Steroids in Asthma: Optimizing Effects in the Airways