Chest
Clinical InvestigationsExerciseReproducibility of Maximal Exercise Ergometer Testing in Patients With Cystic Fibrosis
Section snippets
Patients
Characteristics of our study population are outlined in Table 1. The subjects (six men and three women) were recruited from outpatients in the National Adult Cystic Fibrosis Unit, St. Vincent's University Hospital. All subjects had clinical, radiologic, and physiologic evidence of CF-related lung disease, and they all had CF diagnoses based on clinical features, abnormal sweat test (sweat sodium and chloride > 60 mmol/L), and genotyping. All subjects were clinically stable for a period of 2
Results
All subjects completed each exercise test without any complications, and no exercise test was terminated by the physician.
Discussion
As in previous studies1234567 of exercise in patients with CF, our patients showed reduced exercise tolerance with reduced maximal workload and o2max. Our patients had increased ventilatory requirements with a high ventilation (e), an elevated ventilatory equivalent for oxygen (e/o2) and an increased e/MVV at end exercise. Two patients reached their predicted maximum HR. The three patients with the lowest FEV1 showed significant oxygen desaturation during exercise.
We looked at the
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Guidelines for the Evaluation and Treatment of Muscle Dysfunction in Patients With Chronic Obstructive Pulmonary Disease
2015, Archivos de BronconeumologiaExercise Testing in CF, the What and How
2015, Diet and Exercise in Cystic FibrosisReproducibility of maximal cardiopulmonary exercise testing for young cystic fibrosis patients
2013, Journal of Cystic FibrosisNeuromuscular fatigue after maximal exercise in patients with cystic fibrosis
2011, Journal of Electromyography and KinesiologyCitation Excerpt :In the present work, we tested the hypothesis that despite their ventilatory limitations, patients with CF would develop neuromuscular fatigue in exercising muscles following a maximal exercise test. As such, we used a maximal symptom limited test, widely validated and used in clinical and research settings in CF patients (Ehrman, 2009; McKone et al., 1999; Sexauer et al., 2003). All patients and healthy subjects achieved a peak respiratory exchange ratio ⩾ 1.09 and/or a maximum heart rate ⩾ 85% of predicted values, confirming that the test was near the maximal level.
Resting respiratory variables and exercise capacity in adult patients with cystic fibrosis
2010, Respiratory MedicineUse of the Peak Heart Rate Reached During Six-Minute Walk Test to Predict Individualized Training Intensity in Patients With Cystic Fibrosis: Validity and Reliability
2010, Archives of Physical Medicine and Rehabilitation
Supported by the Cystic Fibrosis Research Trust and a researchfellowship grant from the Irish Lung Association (E.F.M.).