Chest
Clinical InvestigationsSystemic SclerosisRelationship Between Abnormalities on High-Resolution CT and Pulmonary Function in Systemic Sclerosis
Section snippets
Study Population
Fifty-two patients with a diagnosis of systemic sclerosis (36 patients with limited scleroderma and 16 patients with diffuse scleroderma) referred consecutively to our institution for further evaluation were included in this study between September 1995 and March 1996. All patients gave their informed consent to participate in the study, which was approved by our local Ethics Committee. Systemic sclerosis was defined according to the American Rheumatism Association criteria.8 There were 51
Results
Twenty-nine patients (patients 1 to 29) were in group A (Table 1), and 23 patients (patients 30 to 52) were in group B (Table 2). There was no significant difference between the two groups regarding age (group A, 55 ± 14.8 years; group B, 52 ± 13.3 years; mean ± SD). There was a difference between the two groups in terms of cutaneous extent of the disease. In group A, 16 patients (55.2%) had limited scleroderma and 13 patients (44.8%) had diffuse scleroderma. In group B, 20 patients had limited
Discussion
In this study, we introduced a new element in the use of lung HRCT in systemic sclerosis that consists of using a previously defined score of 7 to assess the predictive value and specificity of abnormalities on HRCT to predict pulmonary scleroderma as defined by PFT abnormalities. There have been several stages in defining the role of HRCT to assess interstitial lung disease. The first, purely descriptive, stage was to define the semiology of interstitial lung disease on HRCT. Indeed, HRCT
Acknowledgment
The authors are indebted to F. Wolkman and J. Guillut for their technical support, and D. Raine for reviewing the English.
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