Chest
Selected ReportsSulfasalazine Pulmonary Toxicity in Ulcerative Colitis Mimicking Clinical Features of Wegener's Granulomatosis
Section snippets
CASE REPORT
A 27-year-old man had an 18-month history of ulcerative proctosigmoiditis. He had taken sulfasalazine, 1,000 mg po bid, since diagnosis with no disease activity until flares at 3 and 2 months before onset of pulmonary symptoms. Both ulcerative colitis exacerbations were responsive to hydrocortisone enemas and oral prednisone therapy. Two weeks before onset of pulmonary symptoms, treatment with his second prednisone burst was tapered off, and the sulfasalazine dose was increased to 1,000 mg po
DISCUSSION
The present report describes the mimicry of pulmonary aspects of WG by sulfasalazine lung toxicity. We also describe the first report (to our knowledge) of a false-positive c-ANCA in a patient with UC and pulmonary disease.
Traditionally, open lung biopsy has served as the gold standard to diagnose WG. However, in recent years, some authors have suggested that a positive ANCA test result could replace open lung biopsy in patients with no infectious etiology and characteristic manifestations of
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Cited by (58)
59 - Lung Injury Caused by Pharmacologic Agents
2019, Kendig's Disorders of the Respiratory Tract in ChildrenLung Injury Caused by Pharmacologic Agents
2012, Kendig and Chernick's Disorders of the Respiratory Tract in ChildrenEosinophilic Pneumonia in a Patient with Ulcerative Colitis
2007, Radiology Case ReportsCitation Excerpt :Patients commonly present with dyspnea on exertion, fever, chest pain, and cough [2, 3, 4]. Patients' laboratory findings may include eosinophilia and a positive perinuclear staining anti-neutrophilic cytoplasmic antibody (positive p-ANCA typically found in patients with ulcerative colitis) [2, 5]. The sedimentation rate was elevated in our case, but it can be normal [3].
Lung Injury Caused by Pharmacologic Agents
2006, Kendig's Disorders of the Respiratory Tract in ChildrenA Spotlight on Drug-Induced Vasculitis
2022, Current Rheumatology ReportsSerum ANCA as Disease Biomarkers: Clinical Implications Beyond Vasculitis
2022, Clinical Reviews in Allergy and Immunology
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