Chest
Clinical InvestigationsForced Oscillation Technique vs Spirometry to Assess Bronchodilatation in Patients With Asthma and COPD
Section snippets
Patient Selection
Patients included in this study were ambulatory subjects, presenting to the outpatient clinic, and referred by physicians, to the laboratory for routine pulmonary function testing with a bronchodilator test. The patients had a clinical diagnosis of asthma or COPD. All had airway obstruction due to asthma or COPD. Informed consent was obtained from all subjects before inclusion into the study.
Selection criteria included a clinical diagnosis of asthma or COPD, and evidence of airway obstruction
Baseline Lung Function
Anthropometric data and pulmonary function variables in the 42 patients who participated in the study are presented in Table 1. Compared with predicted normal values,13 FEV1 and FEV1/VC were significantly reduced (p<0.0001) and residual volume was significantly elevated in the asthmatic group (p<0.009) and in the COPD group (p<0.0003). In the COPD group, FRC was slightly but significantly higher than predicted normal values (p<0.05).
Respiratory conductance was significantly lower than predicted
Discussion
Therapy with β2-agonists is widely used in patients with COPD to decrease airway obstruction. The bronchodilator effect usually is assessed on the basis of changes in FEV1. However, compared with spirometry, the FOT offers a number of advantages. Due to the little cooperation required from the subject, the technique is applicable in all age groups and particularly in patients where conventional lung function tests are inapplicable, measurements are performed during tidal volume breathing, and
Acknowledgments
The authors wish to thank Dr. André Denjean for his helpful comments.
References (41)
- et al.
Respiratory impedance in normal humans: effects of bronchodilatation and bronchoconstriction
Mayo Clin Proc
(1987) - et al.
A comparison of the effects of anticholinergic and beta2-agonist and combination therapy on respiratory impedance in COPD
Chest
(1992) - et al.
Normal values of total respiratory resistance and reactance determined by forced oscillations
Chest
(1982) - et al.
Theophylline and salbutamol improve pulmonary function in patients with irreversible chronic obstructive pulmonary disease
Chest
(1992) - et al.
Density and frequency dependence of resistance in early airway obstruction
Am Rev Respir Dis
(1987) - et al.
Total respiratory resistance and reactance in patients with asthma, chronic bronchitis, and emphysema
Am Rev Respir Dis
(1991) - et al.
Comparison of the dose-response curves obtained by forced oscillation and plethysmography during carbachol inhalation
Eur Respir J
(1988) - et al.
Measurement of bronchial responsiveness by forced oscillation technique in occupational epidemiology
Eur Respir J
(1994) - et al.
Total respiratory resistance and reactance as a measurement of response to bronchial challenge with histamine
Am Rev Respir Dis
(1989) - et al.
Comparison of forced oscillometry and forced expirations for measuring dose-related responses to inhaled methacholine in asthmatic children
Bull Eur Physiopathol Respir
(1986)
Input respiratory impedance to estimate airway hyperreactivity in children: standard method versus head generator
Eur Respir J
Assessment of reversibility of airflow obstruction
Am J Respir Crit Care Med
Bronchodilator response in chronic pulmonary disease
Am Rev Respir Dis
A comparison of six different ways of expressing the bronchodilating response in asthma and COPD: reproducibility and dependence of prebronchodilator FEV1
Eur Respir J
Lung volumes and forced ventilatory flows: report working party: standardization of lung function tests: European community for steel and coal
Eur Respir J
A microcomputer-based system to calculate respiratory impedance from forced random noise data
Med Biol Eng Comput
Recommendations for measurement of respiratory input impedance by means of the forced oscillation method
Eur Respir Rev
Flow and volume dependence of respiratory mechanical properties studied by forced oscillation
J Appl Physiol
The use of criteria for reversibility and obstruction to define patient groups for bronchodilator trials
Am Rev Respir Dis
Diagnostic value of reversibility of chronic airway obstruction to separate asthma from chronic bronchitis: a statistical approach
Eur Respir J
Cited by (77)
The role of fractional calculus in modeling biological phenomena: A review
2017, Communications in Nonlinear Science and Numerical SimulationSociété de Pneumologie de Langue Française. Guidelines for clinical practice. Management of COPD. Update 2012: Pulmonary function tests
2014, Revue des Maladies RespiratoiresRespiratory Oscillometry and Functional Performance in Different COPD Phenotypes
2024, International Journal of COPDPressure Oscillation in Biomedical Diagnostics and Therapy
2022, Pressure Oscillation in Biomedical Diagnostics and Therapy
Supported by a grant from Caisse Nationale d'Assurance Maladie des Travailleurs Salariés-Institute National de la Santé et de la Recherche Médicale (CNAMTS-INSERM).
Manuscript revision accepted November 29.