Chest
Exercise Testing Revisited: The Response to Exercise in Normal and Atopic Children
Section snippets
Subjects
A sample of 48 normal and 96 atopic children between 6 and 15 years of age participated in the study at the University Children's Hospital, Sarajevo, BosniaHercegovina.
Normal children (n=48; 28 boys and 20 girls, mean age 10.71 [SD 3.12] yr) were selected from the random sample of 55 pupils of 4 primary and 2 secondary schools in Sarajevo. Seven children who had a positive skin prick test or high immunoglobulin E (IgE) levels or both in spite of having no family history, signs, or symptoms of
RESULTS
The results of exercise testing in the normal children are shown in Table 1. For each lung function test there was no significant change in mean value after exercise but there was considerable difference between the ranges of responses across the tests. Chi-square goodness of fit tests were used to confirm that the data follow the normal distribution. Results greater than two standard deviations from the mean were considered abnormal. Using these criteria the normal range was defined as ≤10
DISCUSSION
Exercise testing is an objective method of confirming EIB and is valuable in diagnosing asthma, particularly in pediatric practice. Attempts have been made to standardize exercise testing,20 but widely differing standards are still used to estimate the normal spirometric response to exercise.4, 5, 6, 7, 8, 9 A plea for standardization was made by Godfrey,3 who stated that it is necessary to define the mode of response in a normal population and then to use this distribution to identify those
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A portable triboelectric spirometer for wireless pulmonary function monitoring
2021, Biosensors and BioelectronicsCitation Excerpt :It was calculated to be 2.12 L and the FEV1/FVC ratio was found to be 71%, both of which are listed in Table 1 in detail. Afterwards, the volunteer tester conducted the second test (described as Stage 1) immediately after 15 min of vigorous exercise to simulate abnormal pulmonary function of COVID-19 patients (Custovic et al., 1994; Zavorsky et al., 2019). These results suggest that while FVC and FEV1 decline significantly, FEV1/FVC increases markedly compared to the reference group (Fig. 4D, Table 1, and Supplementary Fig. S14), which is similar to the clinical feature of the discharged COVID-19 patients (Fumagalli et al., 2020).
Exhaled nitric oxide and other exhaled biomarkers in bronchial challenge with exercise in asthmatic children: Current knowledge
2015, Paediatric Respiratory ReviewsCitation Excerpt :EIB, which occurs in 70–90% of asthmatic children, is indicative of poor asthma control, but improves with appropriate asthma therapy [12–15]. A post-exercise FEV1 fall of at least 10% from baseline is diagnostic of EIB [9,16]. The FEV1 fall is more pronounced as asthma severity increases; however, baseline FEV1 does not predict outcomes of exercise testing [11].
Assessment of EIB. What You Need to Know to Optimize Test Results.
2013, Immunology and Allergy Clinics of North AmericaWhy despite the lower prevalence, is asthma more severe in the semiarid region?
2019, Allergologia et ImmunopathologiaCitation Excerpt :Thus, whilst the lowest prevalence of asthma in the semiarid zone (14%) was expected compared to the intermediate climate region (17.9%) and the coast (19.1%), the number of cases of severe asthma attacks episodes (more than double of the other cities) surprised us and the hypothesis that the dry climate could favor this finding needed more elucidation. Epidemiological studies conducted in countries with major climatic variations during the year reported the driest season as the most prevalent for exercise-induced bronchospasm (EIB)17,18 and important research has described the onset of asthma after exercise with patients breathing dry air.19–21 The explanation for these findings may be related to the hyperventilation caused by physical exercise that results in the dehydration of the mucosa of the lower airways, especially in the periciliary fluid, generating an osmotic gradient in relation to epithelial cells that respond rapidly by transferring water.
Dr. Adnan Custovic is supported in the United Kingdom by a grant from Allen & Hanburys Ltd.