Chest
Clinical Investigations: InfectionsComputed Tomographic Diagnosis of Mycobacterium avium-intracellulare Complex in Patients With Bronchiectasis
Section snippets
Material and Methods
The chest CT examinations of 100 outpatients that were prospectively interpreted as showing bronchiectasis were retrospectively reviewed. At the time of initial interpretation, all CT scans at our institution were computer coded by radiologic diagnosis. From a list of all patients with a CT diagnosis of bronchiectasis, we selected the last 100 patients on the list. The primary clinical indications for the CT scans indicated on the referral forms included the following: evaluation of
Results
Of the 100 patients with CT evidence of bronchiectasis, 24 had multiple pulmonary nodules (Table 1), and 21 of these patients had nodules that were predominantly <5 mm in diameter. Three patients had nodules that were predominantly ≥5 mm in diameter. No nodules were >15 mm in diameter. In 19 of the 24 patients, the lung nodules were in the same lobe as the bronchiectasis (Fig 1), and in the 5 other patients, the bronchiectasis and lung nodules were in different lobes. Of 14 patients with
Discussion
Pulmonary infection with MAC has become a more frequently reported cause of infection in both normal and immunocompromised patients.3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 We tested the following hypothesis: bronchiectasis and multiple small lung nodules are indicative of MAC infection or colonization.
We found that the concomitant presence of multiple small well-circumscribed lung nodules and bronchiectasis on CT (Fig 1) is an indication that the patient is likely to have sputum or bronchial
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Cited by (138)
Nontuberculous Mycobacterial Pulmonary Disease: A Clinical and Radiologic Update
2022, Seminars in RoentgenologyCitation Excerpt :Koh et. al. found that coexistence of bronchiectasis and bronchiolitis in more than 5 lobes (where lingula is considered a separate lobe) is highly suggestive of NTM65; high specificity (87%) and sensitivity (80%) for MAC culture positivity were demonstrated when bronchiectasis and nodules occurred in the same lobe.66 As this is primarily an airway disease, mosaic parenchymal attenuation due to small airway obstruction is frequently seen, especially on the exhalation phase of HRCT (Fig. 4).
Comparison of the chest computed tomography findings between patients with pulmonary tuberculosis and those with Mycobacterium avium complex lung disease
2020, Respiratory InvestigationCitation Excerpt :Similarly, in our study, MACLD cases showed more extensive bronchodilation than PTB cases and cases showing bronchiectasis in both the RIL and LL were rarely observed among PTB patients. The CT findings in MACLD have been reported to indicate more centrilobular granular shadows around the areas of bronchodilation [19], with a frequency that is significantly higher than that in PTB patients [9]. In the present study, we evaluated the granular shadows connected to bronchiectasis, and showed that such CT findings were also more frequently observed in MACLD cases than in PTB cases.
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2020, International Journal of Infectious DiseasesUpdate on pulmonary disease due to non-tuberculous mycobacteria
2016, International Journal of Infectious DiseasesMultidetector CT of pulmonary cavitation: Filling in the holes
2015, Clinical RadiologyMycobacterium avium Complex
2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases