Chest
Selected ReportsPropylthiouracil-Induced Nonspecific Interstitial Pneumonia
Section snippets
Case Report
A 62-year-old Asian woman was admitted for dyspnea and cough of 1 month duration. One year before presentation, she received a diagnosis of hyperthyroidism, and she was since treated with propylthiouracil (PTU) (100 mg/d). She had no other specific medical history except hypertension, which was not treated, and she reported no other concomitant medications. She had never smoked and had no specific occupational history. On admission, her vital signs were stable, with oxygen saturation of 97% on
Discussion
PTU is a thioamide drug that suppresses the synthesis of thyroid hormone by inhibiting iodine binding to tyrosine. It has been suggested that the enzymatic action of myeloperoxidase causes the chemical transformation of PTU to a cytotoxic product1; however, the mechanism responsible for the development of PTU-induced interstitial pneumonia (IP) is not clear. A number of adverse effects of PTU have been reported, including fever, agranulocytosis, and skin rash. Among pulmonary complications,
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