Chest
Original ResearchSigns and Symptoms of Chest DiseasesDyspnea-12 Is a Valid and Reliable Measure of Breathlessness in Patients With Interstitial Lung Disease
Section snippets
Subjects
All patients with documented ILD attending specialist outpatient clinics in northwest England between February 2008 and August 2009 were asked to participate. A total of 120 eligible patients were identified, and 101 participated after providing informed written consent. The study was approved by the Salford and Trafford (Greater Manchester, North West, England) Research Ethics Committee (07/H1004/168).
Study Design
For test-retest reliability, participants completed a set of four questionnaires, including
Subject Details
A total of 101 subjects completed the questionnaires at study baseline and 84 at follow-up. Etiologies of ILD were idiopathic pulmonary fibrosis (IPF) (n = 67), asbestosis (n = 18), sarcoidosis (n = 10), connective tissue disease (n = 2), amiodarone toxicity (n = 2), pulmonary Langerhans cell histocytosis (n = 1), and nonspecific interstitial pneumonia (n = 1). The mean ± SD and range of the physiologic and patient-reported outcomes for the study population are summarized in Table 1.
D-12 Scores
There were
Discussion
In this study, we examined the psychometric properties of the D-12 in a cohort of patients with ILD. We found the D-12 to possess excellent test-retest and internal consistency, and its scores correlated significantly and in the expected directions with other patient-reported outcome measures that assess HRQL or psychologic distress.
The results support the validity of the D-12 for assessing dyspnea at baseline and over time in this patient population. The D-12 is short and simple to use,
Acknowledgments
Author contributions: Dr Yorke: contributed to the study concept and design, statistical analysis, and manuscript preparation. She had full access to the data and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Dr Swigris: contributed to the statistical analyses and manuscript preparation.
Ms Russell: contributed to the study concept and design, data collection, and manuscript preparation.
Dr Moosavi: contributed to the study concept and design.
Dr Ng Man
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2022, Journal of Pain and Symptom ManagementCitation Excerpt :D-12 is a patient-reported outcome scale, developed to assess dyspnea severity in cardiopulmonary and cancer diseases. Physical and emotional components of breathlessness were described.31,41-54 D-12 contains 12 items and 2 factors called ‘physical’ and ‘affective’.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).
Funding/Support: This study was funded by Action Medical Research, England. Dr Swigris is supported in part by a Career Development Award from the National Institutes of Health (K23 HL092227).