Chest
Selected ReportsTwo Cases With Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Successfully Treated With Clarithromycin
Section snippets
Case 1
A 70-year-old woman with a history of chronic sinusitis was admitted to our hospital after developing cough and sputum. A medical examination 12 years before admission showed a small consolidative shadow in the left lung (Fig 1A). An enlarged consolidative shadow and a transbronchial biopsy revealed bronchiectasis 4 years earlier. She was diagnosed with sinobronchial syndrome (SBS). However, the consolidative shadow gradually increased in size, and a chest roentgenogram on admission
Discussion
A definitive diagnosis of p-MALToma is obtained after a detailed histologic examination of biopsy specimens is obtained during transbronchial biopsy, radiologically guided transthoracic core-needle biopsy, or surgical lung biopsy. A diagnosis of p-MALToma based on these findings has a favorable prognosis because p-MALToma is an indolent disease with the potential for spontaneous regression and also has a favorable response to surgery, chemotherapy, or radiotherapy. Consequently, Troch et al5
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Maltoma veiled in the lung-a rare case of pulmonary and gastric maltoma
2021, Respiratory Medicine Case ReportsCitation Excerpt :pMALToma generally has a favorable prognosis due to the prospect of spontaneous regression. The survival rate has been reported to be 91%, 59%, and 53% at one year, five years, and ten years respectively [17,20]. Advanced histopathological stage and presence of amyloid in tumor confer a poor prognosis, as does age greater than 70 years, advanced stage IV disease, and elevated beta-2 microglobulin [21].
Xenophagy in cancer
2020, Seminars in Cancer BiologyCitation Excerpt :While using antibiotics for tumor treatment has been well addressed, there are limited studies on antibiotics inducing autophagy for anti-cancer treatment. Clarithromycin, a commonly used macrolide antibiotic against various bacterial infections including Helicobacter, is also shown to have an effect on mucosa-associated lymphoid tissue lymphomas (MALT) and incidentally, Helicobacter infection can lead to initiation and development of MALT [102,103]. Further studies by other groups observed autophagy inhibition by clarithromycin on myeloma cells leading to apoptosis.
Retrospective Analysis of 75 Patients with Pulmonary Mucosa-associated Lymphoid Tissue Lymphoma in China
2015, International Journal of GerontologyCitation Excerpt :In addition, the treatment was various and similar to that presented in other studies. Recently, researchers reported anti-inflammatory treatment with clarithromycin was an effective treatment strategy for pulmonary MALT lymphomas10,11. One limitation of the study was the incomplete epidemiological data and previous medical history.
Antibiotic therapy in nongastrointestinal MALT lymphoma: A review of the literature
2013, BloodCitation Excerpt :According to these data, the exact role of various pathogens in the lymphomagenesis of bronchus-associated lymphoid tissue lymphoma remains somewhat speculative, and data on antibiotic therapy in patients with pulmonary MALT lymphoma are relatively scarce as no large consistent series have been published so far. Activity of antibiotic therapy has recently been reported by Ishimatsu and coworkers40 who presented 2 cases of bronchus-associated lymphoid tissue lymphoma. In 1 case, a 70-year-old woman treated with combined chemotherapy followed by radiotherapy achieved only a small reduction of the tumor by these measures.
Macrolides for Cancer
2024, Progress in Inflammation ResearchBacterial infection and non-hodgkin b-cell lymphoma: Interactions between pathogen, host and the tumor environment
2021, International Journal of Molecular Sciences
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