Chest
Original ResearchPulmonary HypertensionSurvival in Sarcoidosis-Associated Pulmonary Hypertension: The Importance of Hemodynamic Evaluation
Section snippets
Materials and Methods
Patients at the University of Cincinnati Sarcoidosis and Interstitial Lung Disease Clinic were eligible for this study. All patients in this clinic are entered into a database and information regarding right-sided heart catheterization has been collected prospectively for the past 7 years. All patients eligible for this study were diagnosed with sarcoidosis based on standard criteria,17 and they underwent right-sided heart catheterization for persistent moderate-to-severe dyspnea and at least 6
Results
One hundred thirty patients with sarcoidosis underwent right-sided heart catheterization, revealing 50 (38.5%) patients with PH without LVD and 20 (15.4%) patients with PH/LVD. Figure 1 summarizes the outcome of the catheterizations, including the survival of patients. At the end of the study, all patients were either accounted for by clinic visits or had died.
Table 1 summarizes the characteristics of the three groups studied. No race, age, or gender differences were identified among the three
Discussion
For patients with sarcoidosis, the rate of PH has been reported to be between 5% and 15%.3, 5 In studies of patients with dyspnea, the percentage of patients with PH has been reported as > 50%.2, 4 The current study evaluated right-sided heart catheterization findings in 130 patients with sarcoidosis with persistent moderate to severe dyspnea despite antiinflammatory therapy for sarcoidosis. We did not have a standard protocol for referring patients for right-sided heart catheterization. We did
Acknowledgments
Author contributions: Dr Baughman: contributed to the design of the study, the care of patients, obtaining data on patients, and writing, reading, and approving the manuscript.
Dr Engel: contributed to the design of the study, the care of patients, obtaining data on patients, and writing, reading, and approving the manuscript.
Ms Taylor: contributed to the care of patients, obtaining data on patients, and reading and approving the manuscript.
Dr Lower: contributed to the design of the study, the
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