Chest
Original ResearchCOPDChronic Renal Failure: A Neglected Comorbidity of COPD
Section snippets
Design Overview
We used data coming from the Extrapulmonary Consequences of COPD in the Elderly study, a population-based observational study of white patients with COPD aged 65 years and older aimed at exploring extrapulmonary consequences of COPD. The diagnosis of COPD conformed to American Thoracic Society/European Respiratory Society guidelines.21 To be included in the study, patients had to be in a stable condition and with no physical findings or symptoms suggestive of acute exacerbation or therapy
Results
The mean age of enrolled patients was 75.4 years (SD 6.1, range 61-92), 19.7% of them were women. The mean serum creatinine concentration was 1.06 mg/dL (SD 0.40), and the mean estimated GFR was 64.2 mL/min/1.73 m2 (SD 19.2). The control group had a similar mean age (73.9 years, SD 7.9, range 59-89), and 21.0% of them were women. The mean serum creatinine in the control group was 1.05 (SD 0.55), and the mean estimated GFR was 75.4 mL/min/1.73 m2 (SD 22.4). The most common main diseases in the
Discussion
This study shows that CRF is highly prevalent in an elderly population with COPD and associates with selected nonrespiratory comorbidities. While serum creatinine greater than 1.26 mg/dL for men and 1.04 mg/mL for women30 is a reliable marker of CRF, the GFR is frequently depressed despite normal serum creatinine, mainly in women and older patients.
The estimated prevalence of CRF in the population with COPD was greater than that observed in the control population with a comparable burden of
Acknowledgments
Author contributions: Dr Antonelli Incalzi: participated in the study design, data analysis and interpretation, and manuscript preparation.
Dr Corsonello: participated in data collection, data analysis, and manuscript preparation, and can vouch for the data.
Dr Pedone: participated in data collection, data analysis, and manuscript preparation.
Dr Battaglia: participated in data collection, data analysis, and manuscript preparation, and can vouch for the data.
Dr Paglino: participated in data
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