Chest
Original ResearchCOPDPrior TB, Smoking, and Airflow Obstruction: A Cross-Sectional Analysis of the Guangzhou Biobank Cohort Study
Section snippets
Participants
The Guangzhou Biobank Cohort Study, a collaboration between the Guangzhou Number 12 People's Hospital and the Universities of Birmingham and Hong Kong, has been described in detail previously.19, 20 Recruitment of participants drew from the Guangzhou Health and Happiness Association for the Respectable Elders, a community social and welfare association unofficially aligned with the municipal government whose membership is open to older persons for a monthly fee of 4 yuan (50 US cents). About 7%
Results
Of the 20,431 participants, 8,145 had available information on relevant variables and valid spirometric data (Fig 1). Among them, 79 participants were removed because of radiologic evidence suggestive of active TB. Thus, the final study sample included 8,066 participants, of whom 5,933 (73.6%) were women and 2,133 (26.4%) were men, with an overall mean age of 61.9 years (SD 6.9). Participants who were included for analysis were similar to those who were excluded because of insufficient
Discussion
In a sample of older people from a TB-prevalent region in Asia, we found that radiologic evidence suggestive of inactive TB was associated with a higher risk of airflow obstruction. Furthermore, we did not find evidence to suggest the relationship was modified by smoking.
Our finding is in accordance with a previous study conducted in TB patients6 and two small-scale case-control studies.7, 11 Snider and colleagues6 found that heavy smoking (≥20 cigarettes per day) and more severe TB
Acknowledgments
Author contributions: Dr K.-b. H. Lam: contributed to the quality control of spirometry data in the Guangzhou Biobank Cohort Study, conceived the idea for the paper and developed the approach, analyzed the data, drafted the paper, contributed to the development of the paper, and commented on and approved the final version.
Dr Jiang: helped to conceive the Guangzhou Biobank Cohort Study, contributed to the development of the paper, and commented on and approved the final version.
Dr Jordan:
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Funding/Support: The Guangzhou Biobank Cohort Study was funded by The University of Hong Kong Foundation for Educational Development and Research, the Guangzhou Public Health Bureau, the Guangzhou Science and Technology Bureau, and The University of Birmingham.
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