Chest
Original ResearchSleep MedicineObstructive Sleep Apnea Is Common in Idiopathic Pulmonary Fibrosis
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Subjects
This study was approved by the Vanderbilt Institutional Review Board. Sixty-eight subjects visiting the Vanderbilt Pulmonary Clinic for the follow-up of IPF between August 2006 and February 2008 who met study criteria were asked to participate. The study criteria included the following: age > 18 years; ability to provide informed consent; stable dyspnea; and a confirmed diagnosis of IPF by the American Thoracic Society 2000 consensus statement criteria.8 To include an unbiased representative
Results
Forty-four of 50 subjects (88%) had OSA as defined by an AHI of > 5 events per hour. Ten subjects (20%) had mild OSA (AHI, 5 to 15 events per hour), and 34 subjects (68%) had moderate-to-severe OSA (AHI > 15 events per hour). The subject demographic data in relation to the AHI are shown in Table 1. Age was well matched across AHI categories. The BMI and neck circumference increased with an increase in AHI. The BMI only weakly correlated (BMI: r = 0.30; p = 0.05; Neck circumference: r = 0.23; p
Discussion
We believe that our study represents the first prospective study of OSA in patients who were given a diagnosis of IPF according to the American Thoracic Society 2000 consensus statement criteria.8 The vast majority of patients (88%) had OSA as defined by an AHI of > 5 events per hour. Sleep-disordered breathing in this population predominantly manifested as hypopneas rather than apneas. Neither oxygen saturation nor oxygen use predicted AHI or the severity of desaturation. FVC, lung volumes,
Acknowledgments
Author contributions: Drs. Lancaster, Rice, Loyd, Milstone, Collard, and Malow, Ms. Mason, and Mr. Parnell meet the criteria of authorship as a group, as outlined by CHEST Authorship and Contributorship requirements. As the principal investigator, Dr. Lancaster had complete access to all the data, and takes full responsibility for the reliability of the data and the accuracy of the data analysis. Ms. Mason, the corresponding author, bears full responsibility for the absolute integrity of the
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This study was completed at Vanderbilt University Medical Center.
Funding/Support: This work was supported by the National Center for Research Resources [grant No. HL081431] and Vanderbilt Clinical and Translational Science Award (CTSA) grant one UL1 RR024975.
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