Chest
Original ResearchQuality of LifeHealth-Related Quality of Life Trajectories Among Adults With Tuberculosis: Differences Between Latent and Active Infection
Section snippets
Study Sample
Study subjects were recruited from the Provincial TB Clinic during 2005/2006. Ethics approval was obtained from the University of British Columbia Behavioral Research Ethics Board. Each subject provided signed, informed consent to participate in the study. Consecutive patients > 18 years of age with either LTBI or active TB disease were approached regarding entry into the study. Subjects were excluded for the following: (1) they were < 18 years old; (2) they were not receiving medication for
Results
In a consecutive fashion, over a 12-month period we approached 147 LTBI and 133 active TB patients to participate in the study. Of these, 119 LBTI and 114 active TB patients were deemed eligible and consented to participate in the study. Of these, 27 patients (17 LBTI and 7 active) withdrew from the study prior to completing the questionnaires. Subsequent to enrollment, three patients reported as having active TB were excluded because they did not fit the entry criteria of having active TB
Discussion
In this study, at the onset of treatment, participants with active TB had bigger deficits in HRQL than LTBI participants compared to US population norms. However, after 6 months of drug therapy, participants with active disease significantly improved in most domains of HRQL whereas those with LTBI did not. The domains that improved the most in active TB participants were vitality, physical functioning, role physical, social functioning, and role emotional. However, despite these significant
ACKNOWLEDGMENT
We thank Greg Stark, TB program nurse, for his aid in patient recruitment.
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This study was funded by a grant from the Canadian Society of Hospital Pharmacists. Dr. C. Marra is a Canada Research Chair in Pharmaceutical Outcomes as well as a Michael Smith Foundation for Health Research Scholar. Dr. Fitzgerald is a BC Lung CIHR Scientist and a Michael Smith Foundation for Health Research Distinguished Scholar.
The authors have no conflicts of interest to disclose.