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ORIGINAL RESEARCHPULMONARY HYPERTENSIONPulmonary Hypertension and Thyroid Disease
Section snippets
Patients
This study was approved by the Mayo Clinic Institutional Review Board. All patients with PH seen at Mayo Clinic Jacksonville Pulmonary Hypertension Center from 1992 to 2006 were studied retrospectively. A sex-matched control group was randomly selected from a list of patients seen in the Pulmonary Clinic at Mayo Clinic for diseases other than PH. In the study group, 8 of 364 patients were excluded because they had normal right-heart catheterization (RHC) pressures. Of the 700 control patients,
Results
Baseline characteristics of the 356 PH patients, including age, sex, TSH levels, and WHO symptom class, stratified by WHO group, were compared with those of the 698 patients in the control group (Table 1). The entire PH group and WHO group 1 patients were slightly younger. The control group of 698 patients had the same sex ratio as the entire PH group by design; however, the WHO group 1, particularly the IPAH group, had a higher percentage of female patients. The combined WHO groups 2, 3, and 4
Discussion
Our data indicate a prevalence (24%) of thyroid disease in PH similar to that reported in previous studies.41316 Curnock et al13 reported a prevalence of 23% in 40 patients with primary PH. The association was strongest in WHO group 1 PAH patients, most notably in our group of IPAH patients, in whom the prevalence was 30%. Ferris et al4 retrospectively reviewed 134 adults with PH (most with IPAH and PAH in association with collagen vascular disease) and found that 26 patients (19%) had thyroid
Conclusions
To our knowledge, this is the first study to have an adequate control group with which to compare PH patients regarding the prevalence of thyroid disease, and our findings indicate a difference in the prevalence of thyroid disease between these two groups. Screening for thyroid dysfunction in patients with PH has been advocated as a mechanism to identify possible alternative exacerbating factors.926 The findings of our study support the contention that a significant percentage of PH patients
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Editing, proofreading, and reference verification were provided by the Section of Scientific Publications, Mayo Clinic.
The authors have no conflicts of interest or financial involvement with this article.