Chest
ORIGINAL RESEARCHPULMONARY VASCULAR DISEASEPrognostic Models for Selecting Patients With Acute Pulmonary Embolism for Initial Outpatient Therapy
Section snippets
Study Design
For a prospective registry, we attempted to enroll all patients with a diagnosis of acute PE between January 1, 2003, and September 30, 2006. Using prospectively collected baseline data at the time of PE diagnosis and outcome data from this cohort, we retrospectively assessed the test characteristics of the Geneva prognostic model and the PESI for predicting 30-day mortality, nonfatal recurrent venous thromboembolism (VTE), and nonfatal major bleeding. We also compared the performance of both
Results
Of the 2,219 patients evaluated for possible acute symptomatic PE during the study period, 624 patients (28%) had objectively confirmed PE. Of these, 9 patients (1.4%) refused to give informed consent, producing a study sample of 615 patients. Since 16 patients (2.6%) were unavailable for follow-up, the evaluable population consisted of 96.0% (599 patients) of eligible patients with acute PE.
Compared to patients in the PESI derivation sample,7 patients in this validation cohort more frequently
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2019, Medical Clinics of North AmericaCitation Excerpt :Table 2 highlights the PESI and sPESI scores. Multiple studies have demonstrated that patients with low PESI scores (group I) had mortality less than 1% compared with high PESI group (group V) with 24% 30-day mortality.33–35 D-dimer is a fibrin degradation product.
Drs. D. Jiménez, R. Otero, F. Uresandi, D. Nauffal, E. Laserna, F. Conget, M. Oribe, and M.A. Cabezudo are investigators in the Cooperative Study for the Ambulatory Treatment of Patients With Pulmonary Embolism research group.
Then authors have no conflicts of interest to disclose.