Effect of inhaled corticosteroids on the hypothalamic-pituitary-adrenal axis and growth in children

doi:10.1067/mpd.2000.109793

The Journal of Pediatrics

Volume 137, Issue 4, October 2000, Pages 450-454

https://doi.org/10.1067/mpd.2000.109793 Get rights and content

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Two CF patients developed Cushing's syndrome during administration of inhaled budesonide (400 μg/d) with oral itraconazole in one and with clarithromycin in the other patient. Clinical features appeared respectively after 2 and 6 weeks of drug co-administration, with prolonged adrenal suppression, and a slow recovery after ceasing the drugs. Inhibitors of the cytochrome P450 interfere with the metabolism of corticosteroids. Combination of these drugs even with moderate doses of budesonide should be closely monitored.
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^☆: Reprint requests: Lenore S. Levine, MD, Babies and Children’s Hospital of New York, Columbia Presbyterian Medical Center, 630 West 168th St, PH 5 East 522, New York, NY 10032.

^☆☆: J Pediatr 2000;137:450-4.

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Medical ProgressEffect of inhaled corticosteroids on the hypothalamic-pituitary-adrenal axis and growth in children☆,☆☆

First page preview

Ann Allergy Asthma Immunol

J Pediatr

J Pediatr

Lancet

Lancet

J Allergy Clin Immunol

J Allergy Clin Immunol

J Pediatr

J Pediatr

J Urol

Inhaled corticosteroids and growth in children

Pediatr Ann

The British guidelines on asthma management: 1995 review and position statement

Thorax

Systemic adverse effects of inhaled corticosteroid therapy: a systematic review and meta-analysis

Arch Intern Med

Efficacy and safety of inhaled corticosteroids in asthma

Am Rev Respir Dis

Effect of inhaled beclomethasone dipropionate on hypothalamic-pituitary adrenal axis function in children with asthma

Pediatrics

Fluticasone propionate in children with moderate asthma

Am J Respir Crit Care Med

Treatment of chronic childhood asthma with beclomethasone dipropionate aerosol. I. A double-blind crossover trial in nonsteroid-dependent patients

Pediatrics

Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children

Pediatrics

Growth and pituitary-adrenal function in children with severe asthma treated with inhaled budesonide

N Engl J Med

Medical Progress
Effect of inhaled corticosteroids on the hypothalamic-pituitary-adrenal axis and growth in children☆,☆☆