Vascular endothelial growth factor in patients with acute asthma

https://doi.org/10.1067/mai.2001.115628Get rights and content

Section snippets

To the Editor:

Bronchial asthma is a chronic inflammatory disease of the airways that is characterized by airway remodeling. The histologic characteristics of chronic inflammation include angiogenesis, increased connective tissue deposition, and cellular proliferation of myofibroblasts.1 There is an increase in vessel area in bronchial asthma.2 Vascular endothelial growth factor (VEGF; vascular permeability factor) is one of the most potent proangiogenic cytokines, and it plays a central role in mediating the

References (5)

There are more references available in the full text version of this article.

Cited by (79)

  • Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects

    2011, Journal of Allergy and Clinical Immunology
    Citation Excerpt :

    It is very important to stress here that all 3 essential proinflammatory molecules were downregulated by claudin-1 overexpression. It has been well known that VEGF expression is increased in tissues from asthmatic patients7,29,30 and its levels directly correlate with disease activity.31 Moreover, VEGF induces asthma-like phenotypes, such as inflammation, vascular remodeling, edema, mucous metaplasia, and AHR, and there is more smooth muscle hyperplasia in lung-targeted VEGF-transgenic mice.32

View all citing articles on Scopus
View full text