Mechanisms of allergyHuman eosinophils constitutively express nuclear factor of activated T cells p and c☆
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The role of NFAT in the pathogenesis and targeted therapy of hematological malignancies
2022, European Journal of PharmacologyCitation Excerpt :This protein was initially discovered in 1988 as a T cell activation-specific enhancer of interleukin-2 (IL-2), because this protein complex always appeared to bind the IL-2 promoter 10–25 min before IL-2 gene activation (Shaw et al., 1988). With the further research on NFAT, the investigators found that NFAT proteins are not only expressed in T cells but also in B cells, megakaryocytes, eosinophils, and other immune cells (Seminario et al., 2001; Vaeth and Feske, 2018; Zhao et al., 2021). Some studies had proved that NFAT can mediate multiple adaptive T cell functions by regulating T cell activation, differentiation, and exhaustion (Antony et al., 2003; Hogan, 2017).
NFAT control of innate immunity
2012, BloodCitation Excerpt :The active NFAT pathway in neutrophils is comparably active in basophils83 and eosinophils.84 Eosinophils constitutively express NFAT1 and NFAT285 and can synthesize many NFAT-dependent molecules, including IL-286 and GM-CSF87 on activation. Treatment with calcineurin/NFAT inhibitors leads to impaired degranulation and cytokine release as well as prolonged eosinophil survival.88
Molecular mechanisms of IgE mediated food allergy
2012, International ImmunopharmacologyCitation Excerpt :Its role in protein kinase C (PKC) activation has been revealed but complete exploration regarding its involvement in food allergy is yet to be done [48]. Regulation of expression of cytokines and other genes in eosinophils by subtypes of NFAT, like NFATp and NFATc has been reported but such studies regarding mast cells are still elusive [49]. The other sub types of NFAT i.e., NFATc1 and NFATc2 get accumulated in memory CD4 + T cells, indicating their roles in early activation following antigen attachment [50].
Expression analysis of nuclear factor of activated T cells (NFAT) during myeloid differentiation of CD34<sup>+</sup> cells: regulation of Fas ligand gene expression in megakaryocytes
2007, Experimental HematologyCitation Excerpt :The second aim of the present study was to address the question of whether the expression of NFAT during the differentiation of CD34+ cells into myeloid cells was regulated by lineage-specific mechanisms, similar to known for “classical” myeloid transcription factors, such as PU-1 and GATA. The potential presence of such a mechanism was suggested by two previous observations: First, the distinct and lineage-specific expression pattern of NFAT family members in mature myeloid cells of the peripheral blood [32,46–50], and second, our observation that NFATc2 expression was rapidly and profoundly suppressed when CD34+ cells were differentiated ex vivo into neutrophil granulocytes [32]. Our intention to establish an expression profile of NFAT during myeloid differentiation of CD34+ cells was prompted by the hypothesis that dynamic changes of transcription factor expression levels during the differentiation of given myeloid lineages may indicate a (positive or negative) regulatory function of this transcription factor in these cells.
Selective expression of nuclear factor of activated T cells 2/c1 in human basophils: Evidence for involvement in IgE-mediated IL-4 generation
2002, Journal of Allergy and Clinical ImmunologyUnderstanding the pathogenesis of Kawasaki disease by network and pathway analysis
2013, Computational and Mathematical Methods in Medicine
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Supported in part by research grants from the National Institutes of Health and American Lung Association. Dr Seminario was the recipient of an Underrepresented Minority Investigator in Asthma and Allergy Award from the National Institutes of Health and the American Academy of Allergy, Asthma and Immunology.