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Dampening inflammation

Nature Immunology volume 6, pages 1179–1181 (2005)Cite this article

Abstract

This series of reviews addresses mechanisms whereby inflammation can be reduced, turned off or perhaps prevented, both in the context of natural dampening processes as well as possible approaches to anti-inflammatory therapy. Underlying the central issue is the implication that inflammation is indeed something inherently bad that needs to be dampened. Although this is certainly often the case and it can be argued that most human disease processes include some element of inflammation, nevertheless, inflammation is also natural, beneficial and, indeed, essential. This balance and its possible manipulation is a second theme running through the reviews.

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Figure 1: Inflammation in innate and adaptive immunity.

References

  1. Han, J. & Ulevitch, R.J. Limiting inflammatory responses during activation of innate immunity. Nat. Immunol. 6, 1182–1189 (2005).

    Article  Google Scholar 

  2. Majno, G. The Healing Hand: Man and Wound in the Ancient World (Harvard University Press, Cambridge, 1975).

    Google Scholar 

  3. Luster, A.D., Alon, R. & von Adrian, U.H. Immune cell migration in inflammation: present and future therapeutic targets. Nat. Immunol. 6, 1190–1198 (2005).

    Article  Google Scholar 

  4. Serhan, C.N. & Savill, J. Resolution of inflammation: the beginning programs the end. Nat. Immunol. 6, 1199–1205 (2005).

    Article  Google Scholar 

  5. DeCathelineau, A.M. & Henson, P.M. Programmed cell death: chapter 8. The final step in programmed cell death: phagocytes carry apoptotic cells to the grave. Essays Biochem. 39, 105–117 (2003).

    Article  CAS  Google Scholar 

  6. Gardai, S.J. et al. Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans activation of LRP on the phagocyte. Cell 123, 321–334 (2005).

    Article  CAS  Google Scholar 

  7. Fadok, V.A. et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF. J. Clin. Invest. 101, 890–898 (1998).

    Article  CAS  Google Scholar 

  8. Huynh, M.L., Fadok, V.A. & Henson, P.M. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation. J. Clin. Invest. 109, 41–50 (2002).

    Article  CAS  Google Scholar 

  9. Manderson, A.P., Botto, M. & Walport, M.J. The role of complement in the development of systemic lupus erythematosus. Annu. Rev. Immunol. 22, 431–456 (2004).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Supported by the National Institutes of Health (HL 68864, HL 67671 and GM 61031).

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  1. Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, 80206, Colorado, USA

    Peter M Henson

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  1. Peter M Henson
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Correspondence to Peter M Henson.

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The author declares no competing financial interests.

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Henson, P. Dampening inflammation. Nat Immunol 6, 1179–1181 (2005). https://doi.org/10.1038/ni1205-1179

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