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Preparing the target for the bullet

Nature Immunology volume 3, pages 16–17 (2002)Cite this article

Multiple regulatory cascades control inflammatory gene expression. The responsive loci need to be prepared to bind the inducing regulatory factors, and such changes can be invoked by p38-dependent histone modification.

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Figure 1: Model for p38-dependent NF-κB recruitment at the IL-8 or MCP-1 promoter.

Bob Crimi

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  1. Laboratory of Molecular Immunoregulation, SAIC, National Cancer Institute, Frederick, 21702, MD, USA

    Kathrin Muegge

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  1. Kathrin Muegge
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Muegge, K. Preparing the target for the bullet. Nat Immunol 3, 16–17 (2002). https://doi.org/10.1038/ni0102-16

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