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Chemokines as regulators of T cell differentiation

Nature Immunology volume 2, pages 102–107 (2001)Cite this article

Abstract

Chemokines play well established roles as attractants of naïve and effector T cells. New studies indicate that chemokines also have roles in regulating T cell differentiation. Blocking Gi protein–coupled receptor signaling by pertussis toxin as well as deficiencies in Gαi2, chemokine receptor 2 (CCR2), CCR5, chemokine ligand 2 (CCL2, also known as monocyte chemoattractant protein 1, or MCP-1), CCL3 (macrophage inflammatory protein 1α, or MIP-1α) and CCL5 (RANTES) have all been found to have effects on the magnitude and cytokine polarity of the T cell response. Here we focus on findings in the CCL2-CCR2 and CCL3-CCR5 ligand-receptor systems. The roles of these molecules in regulating T cell fate include possible indirect effects on antigen-presenting cells and direct effects on differentiating T cells. Models to account for the action of chemokines and G protein–coupled receptor signals in regulating T cell differentiation are discussed.

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Figure 1: Mechanisms by which chemokines may influence T cell differentiation.
Figure 2: Possible pathways of chemokine and Gi protein–coupled receptor-mediated regulation of TH cell polarization.

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Acknowledgements

Supported by the Human Frontiers Science Program (to S. A. L.) and Packard Foundation (to J. G. C.).

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  1. The Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Ave., San Francisco, 94143-0414, CA, USA

    Sanjiv A. Luther & Jason G. Cyster

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Luther, S., Cyster, J. Chemokines as regulators of T cell differentiation. Nat Immunol 2, 102–107 (2001). https://doi.org/10.1038/84205

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