Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Pulling apart pulmonary hypertension

Defective TFG-β signalling through the bone morphogen receptor type II is implicated in autosomal dominant and sporadic primary pulmonary hypertension. This fatal disorder is characterized by vascular remodelling, often triggered by the use of appetite-suppressant drugs which were, until recently, used to treat obesity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Purchase on Springer Link

Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A feature of primary pulmonary hypertension is the plexiform lesion (a) that arises from disruption of endothelial cells of the pulmonary arteries.
Figure 2: The TGF-β-signalling pathway.

References

  1. Trembath, R.C. et al. Nature Genet. 26, 81– 84 (2000).

    Article  Google Scholar 

  2. Nichols, W.C. et al. Nature Genet. 15, 277– 280 (1997).

    Article  CAS  Google Scholar 

  3. Knowles, J.A. et al. Am. J. Hum. Genet. 67, 737– 744 (2000).

    Article  Google Scholar 

  4. Nichols, W.C. et al. J. Med. Genet. (in press).

  5. Massagué, J. & Chen, Y. Genes Dev. 14, 627–644 (2000).

    PubMed  Google Scholar 

  6. Shovlin, C. J. Clin. Invest. 104, 1335–1336 (1999).

    Article  CAS  Google Scholar 

  7. Lee, S.-D. J. Clin. Invest. 101, 927–934 (1998).

    Article  CAS  Google Scholar 

  8. Lu, S.-L. Nature Genet. 19, 17–18 (1998).

    Article  CAS  Google Scholar 

  9. Moore, L.G. N. Engl. J. Med. 333, 1248 (1995 ).

    Article  Google Scholar 

  10. Aguirre, J.I. et al. Am. J. Physiol. 278, 981– 987 (2000).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Scott, J. Pulling apart pulmonary hypertension. Nat Genet 26, 3–4 (2000). https://doi.org/10.1038/79148

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/79148

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing