Abstract
THE macrophage scavenger receptor, which has been implicated in the pathogenesis of atherosclerosis1,2, has an unusually broad binding specificity1. Ligands include modified low-density lipoprotein and some polyanions (for example, poly(I) but not poly(C)). The scavenger receptor type I (ref. 3) has three principal extracellular domains that could participate in ligand binding: two fibrous coiled-coil domains (α-helical coiled-coil domain IV and collagen-like domain V), and the 110-amino-acid cysteine-rich C-terminal domain VI. We have cloned complementary DNAs encoding a second scavenger receptor which we have termed type II. This receptor is identical to the type I receptor, except that the cysteine-rich domain is replaced by a six-residue C terminus. Despite this truncation, the type II receptor mediates endocytosis of chemically modified low-density lipoprotein with high affinity and specificity, similar to that of the type I receptor. Therefore one or both of the extracellular fibrous domains are responsible for the unusual ligand-binding specificity of the receptor.
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References
Brown, M. S. & Goldstein, J. L. A. Rev. Biochem. 52, 223–261 (1983).
Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C. & Witztum, J. L. New Engl. J. Med. 320, 915–924 (1989).
Kodama, T. et al. Nature 343, 531–535 (1990).
Esser, V., Limbird, L. E., Brown, M. S., Goldstein, J. L. & Russell, D. W. J. biol. Chem. 263, 13282–13290 (1988).
Kodama, T., Reddy, P., Kishimoto, C. & Krieger, M. Proc. natn. Acad. Sci. U.S.A. 85, 9238–9242 (1988).
Brandan, E., Maldonado, M., Garrido, J. & Inestrosa, N. C. J. Cell Biol. 101, 985–992 (1985).
Ross, G. F., Notter, R. H., Meuth, J. & Whitsett, J. A. J. biol. Chem. 261, 14283–14291 (1986).
Colley, K. J. & Baenziger, J. U. J. biol. Chem. 262, 10296–10303 (1987).
Rosenberg, A. M., Prokopchuk, P. A. & Lee, J. S. J. Rheum. 15, 1091–1096 (1988).
Tall, A. R., Small, D. M. & Lees, R. S. J. Clin. Invest. 62, 836–846 (1978).
Frank, J. S. & Fogelman, A. M. J. Lipid Res. 30, 967–978 (1989).
Takagi, J., Kasahara, K., Sekiya, F., Inada, Y. & Saito, Y. J. biol. Chem. 264, 10425–10430 (1989).
Phillips, D. R., Arnold K. & Innerarity, T. L. Nature 316, 746–748 (1985).
Hoover, G. A., McCormick, S., & Kalant, N. Arteriosclerosis 8, 525–534 (1988).
Miller, E. J. & Gay, S. Meth. Enzym. 144, 3–41 (1987).
Dresel, H. A. et al. EMBO J. 6, 319–326 (1987).
Sparrow, C. P., Parthasarathy, S. & Steinberg, D. J. biol. Chem. 264, 2599–2604 (1989).
Arai, H., Kita, T., Yokode, M., Narumiya, S. & Kawai, C. Biochem. biophys. Res. Commun. 159, 1375–1382 (1989).
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Rohrer, L., Freeman, M., Kodama, T. et al. Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Nature 343, 570–572 (1990). https://doi.org/10.1038/343570a0
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DOI: https://doi.org/10.1038/343570a0
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