Elsevier

Genomics

Volume 89, Issue 5, May 2007, Pages 618-629
Genomics

Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner

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Abstract

Gasdermin (Gsdm) was originally identified as a candidate causative gene for several mouse skin mutants. Several Gsdm-related genes sharing a protein domain with DFNA5, the causative gene of human nonsyndromic hearing loss, have been found in the mouse and human genomes, and this group is referred to as the DFNA5–Gasdermin domain family. However, our current comparative genomic analysis identified several novel motifs distinct from the previously reported domain in the Gsdm-related genes. We also identified three new Gsdm genes clustered on mouse chromosome 15. We named these genes collectively the Gsdm family. Extensive expression analysis revealed exclusive expression of Gsdm family genes in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Further database searching revealed the presence of other related genes with a similar N-terminal motif. These results suggest that the Gsdm family and related genes have evolved divergent epithelial expression profiles.

Keywords

Gsdm family
Dfna5
Dfnb59 (pejvakin)
Gastrointestinal tract
Epithelium
Gene duplication
Evolution

Cited by (0)

The nomenclature used in this article has not been approved by the human and mouse gene nomenclature committees. However, it is hoped that this article will start a discussion within the community that could lead to a new nomenclature.

1

These authors contributed equally to this work.